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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant Rat IL-2. Rat IL-2 specific antibody was purified by affinity chromatography employing immobilized Rat IL-2 matrix.
- 保存条件:
IL-2 antibody is stable for at least 2 years from date of receipt at -20℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
E, WB, Neut
- 抗体英文名:
IL-2 Antibody
- 抗体名:
IL-2 Antibody
- 规格:
0.1mg
IL-2 抗体,IL-2 Antibody,IL-2 抗体,IL-2 Antibody
产品名称:IL-2 抗体-IL-2 Antibody
产品货号:PSI-38-204-0.1mg
产品规格:0.1mg
背景资料:Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.
保存建议:IL-2 抗体-IL-2 AntibodyIL-2 antibody is stable for at least 2 years from date of receipt at -20℃
应用类型:E, WB, Neut
点击:IL-2 抗体-IL-2 Antibody查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验协同刺激信号促进IL-2基因转录的机制 经由钙调磷酸酶激活的转录因子NF-AT虽可进人细胞核,但是在组成性表达的一种称为糖原合成酶激酶(GSK3)的作用下,重新从胞核逸出,致使核内无足够浓度的NF-AT可以和启动子区相应的顺式作用元件结合,IL-2基因转录受阻。此时,CD28启动的信号途径中激活的P1 3K,可以作用于GSK3,使其丧失介导NF-AT的胞核外流作用,NF-AT浓度遂迅速升高,使IL-2基因的转录以致整个T细胞的激活成为可能。
IL-2 的体外诱生 IL-2主要由活化的CD4+ T细胞产生,主要是促进T淋巴细胞的增殖与分化。IL-2是机体免疫网络中最重要的细胞因子,因此IL-2的检测已成为评价机体免疫功能状态的重要指标之一。但由于IL-2是通过自分泌或旁分泌方式发挥其生物学效应的,在生理性免疫应答过程中,IL-2不出现于血液等体液中,故体液中IL-2含量极少,难以直接测定,通常是通过检测体外诱生的IL-2来反映体内IL-1活性水平。IL-2可用免疫学方法来检测其含量,但更多是用生物
Human IL-2 Enzyme Immunoassay (EIA)
natural killer cells and tumor-infiltrating lymphocytes plus the enhancement of the ability of theses cytotoxic lymphocytes to kill targets cells Stimulus for the division of antibody-producing B cells Up regulation of IL-2 receptors on T cells
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