Thymidylate Synthase 抗体 [SPM45

Thymidylate Synthase 抗体 [SPM453]，Thymidylate Synthase Antibody [SPM453]，Thymidylate Synthase 抗体 [SPM453],Thymidylate Synthase Antibody [SPM453]

产品名称：Thymidylate Synthase 抗体 [SPM453]-Thymidylate Synthase Antibody [SPM453]

产品货号：PSI-34-176-100ug

产品规格：100ug

背景资料：It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

保存建议：Thymidylate Synthase 抗体 [SPM453]-Thymidylate Synthase Antibody [SPM453]Aliquot and Store at 2-8℃

应用类型：Flow, IF, IHC

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