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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Mouse p27Kip1 protein was used as the immunogen for this p27 antibody.
- 保存条件:
Aliquot and Store at 2-8℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
小鼠
- 应用范围:
Flow, IF, WB, IHC
- 抗体英文名:
p27Kip1 Antibody [SPM348]
- 抗体名:
p27Kip1 Antibody [SPM348]
- 规格:
100ug
p27Kip1 抗体 [SPM348],p27Kip1 Antibody [SPM348],p27Kip1 抗体 [SPM348],p27Kip1 Antibody [SPM348]
产品名称:p27Kip1 抗体 [SPM348]-p27Kip1 Antibody [SPM348]
产品货号:PSI-34-091-100ug
产品规格:100ug
背景资料:This mAb recognizes a 27kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. p27Kip1 functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene.
保存建议:p27Kip1 抗体 [SPM348]-p27Kip1 Antibody [SPM348]Aliquot and Store at 2-8℃
应用类型:Flow, IF, WB, IHC
点击:p27Kip1 抗体 [SPM348]-p27Kip1 Antibody [SPM348]查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验-induced responses, including a down-regulation of the cyclin-dependent kinase (Cdk2) inhibitors p21CIP1 and p27KIP1 , while attachment to P-L-L did not. We conclude that engagement of the FN-receptor integrin α5β1 induces integrin signaling regulating
will elucidate the relationship of EGFR and tumor、the progession of monocolonal antibody in tumor therapy.【key words】 Epidermal Growth Factor Receptor monocolonal antibody tumor thearpy单克隆抗体治疗是近年来兴起的一项治疗肿瘤的方法,其高均一性、高特异性和安全的特点给肿瘤治疗带来了新希望。表皮生长因子受体(EGFR)表达于多种肿瘤
期)细胞中发现的。在静止细胞中 RB 是未被磷酸化, Dcyclin 的水平是低的或者缺如, p16 , p21 和 p27 蛋白使 cdk-cyclin 失活。 p21(cip1/wAF1),p27(Kip1) 和 p15/p16 ( ink4 )合称为Cki 蛋白 ,它们结合在 cdk-cyclin 二聚体上,使其失活。如在静止期通过这种途径阻止 RB 的磷酸化,使细胞周期不能进入 S 期。 p15/p16 是由两个相邻的基因编码,二者密切
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