Thomsen-Friedenreich Antigen 抗

Thomsen-Friedenreich Antigen 抗体 [A68-B/A11]，Thomsen-Friedenreich Antigen Antibody [A68-B/A11]，Thomsen-Friedenreich Antigen 抗体 [A68-B/A11],Thomsen-Friedenreich Antigen Antibody [A68-B/A11]

产品名称：Thomsen-Friedenreich Antigen 抗体 [A68-B/A11]-Thomsen-Friedenreich Antigen Antibody [A68-B/A11]

产品货号：PSI-33-541-100ug

产品规格：100ug

背景资料：Recognizes a disaccharide epitope, Gal1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF, including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The Thomsen-Friedenreich antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. It is considered as a pan-carcinoma marker. During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. The tumor-associated carbohydrate Thomsen-Friedenreich antigen (Gal-GalNAc) is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. The Thomsen-Friedenreich antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. The presence of the Thomsen-Friedenreich antigen on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells, most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide.

保存建议：Thomsen-Friedenreich Antigen 抗体 [A68-B/A11]-Thomsen-Friedenreich Antigen Antibody [A68-B/A11]Aliquot and Store at 2-8℃

应用类型：IF, IHC-P

点击：Thomsen-Friedenreich Antigen 抗体 [A68-B/A11]-Thomsen-Friedenreich Antigen Antibody [A68-B/A11]查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。