CD32 抗体 [8.7]-CD32 Antibody [8

CD32 抗体 [8.7]，CD32 Antibody [8.7]，CD32 抗体 [8.7],CD32 Antibody [8.7]

产品名称：CD32 抗体 [8.7]-CD32 Antibody [8.7]

产品货号：PSI-33-355-100ug

产品规格：100ug

背景资料：This mAb reacts with a CD32 (FcgRII) epitope distinct from that defined by mAb 8.26 and the epitope overlaps with that of mAb 7.30 (cluster 4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcgRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.

保存建议：CD32 抗体 [8.7]-CD32 Antibody [8.7]Aliquot and Store at 2-8℃

应用类型：WB, Func, Flow, IF

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