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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant HIV-1 Gag p24 protein was used as the immunogen for this antibody.
- 保存条件:
Aliquot and Store at 2-8℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
小鼠
- 应用范围:
ICC, IF, E
- 抗体英文名:
HIV Type-1 p24 Antibody [HIV1-24/661]
- 抗体名:
HIV Type-1 p24 Antibody [HIV1-24/661]
- 规格:
100ug
HIV Type-1 p24 抗体 [HIV1-24/661],HIV Type-1 p24 Antibody [HIV1-24/661],HIV Type-1 p24 抗体 [HIV1-24/661],HIV Type-1 p24 Antibody [HIV1-24/661]
产品名称:HIV Type-1 p24 抗体 [HIV1-24/661]-HIV Type-1 p24 Antibody [HIV1-24/661]
产品货号:PSI-33-250-100ug
产品规格:100ug
背景资料:Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.
保存建议:HIV Type-1 p24 抗体 [HIV1-24/661]-HIV Type-1 p24 Antibody [HIV1-24/661]Aliquot and Store at 2-8℃
应用类型:ICC, IF, E
点击:HIV Type-1 p24 抗体 [HIV1-24/661]-HIV Type-1 p24 Antibody [HIV1-24/661]查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验The Design, Production, and Validation of an Anti-HIV Type 1 Ribozyme
(3 ,4 ) with an immune response evident, namely antibodies to env and p24 as well as HIV specific cytotoxic T-lymphocytes (5 ).
以及病毒标志物已经被用于诊断,但它们在HIV感染的发展过程中会不停地改变着。在HIV感染的最初几天中,病毒会开始活跃复制,这使得病毒RNA的检测成为可能。不久之后可以检测病毒抗原(蛋白)。在HIV诊断中检测最多的是衣壳蛋白p24,这一般会在急性感染后的两到三个星期内出现。p24在血清中出现的时间较为短暂,会随着体液和细胞免疫的发展而消失。通常最先出现的抗体是抗衣壳或包膜蛋白IgM抗体,但存在时间较短,随后出现的是IgG抗体。IgG抗体针对的是核(p24)以及包膜(gp160、120、41)蛋白,跟随
1、ELISA :对gp41 HIV 1型抗体的检测 是标准的筛选方法,敏感性可达99.5%,但特异性并不高。该法的阳性者中仅13%为真正的HIV者,因此,属筛选试验。 2、蛋白印迹(Western印迹)法:是最常用的证实实验。若检出所有3个HIV主要基因gag、po1、env产物的抗体时为阳性,可确诊为HIV感染。 3、HIV1型抗原检测 由于血中p24抗原浓度低且形成了免疫复合物,p24抗原检测阳性率不如抗体阳性率高。在HIVl型感染的无症状
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