p53 抗体 [BP53-12]-p53 Antibody

p53 抗体 [BP53-12]，p53 Antibody [BP53-12]，p53 抗体 [BP53-12],p53 Antibody [BP53-12]

产品名称：p53 抗体 [BP53-12]-p53 Antibody [BP53-12]

产品货号：PSI-33-217-100ug

产品规格：100ug

背景资料：This antibody is specific for a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. The antibody epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. antibody to p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

保存建议：p53 抗体 [BP53-12]-p53 Antibody [BP53-12]Aliquot and Store at 2-8℃

应用类型：WB, Flow, IHC, IF

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