- ￥22
- ProSci
- 美国
- PSI-33-138-100ug
- 2025年07月06日
- ICC, Flow, IF
- 小鼠
企业认证
相关产品推荐更多 >
NPNT纯化的MaxPab小鼠源多克隆抗体(B01P) | NPNT purified MaxPab mouse polyclonal antibody (B01P)
询价
iFluor™ 670 Anti-human CD102 Antibody *CBR-IC2/2*/iFluor™ 670 Anti-human CD102 Antibody *CBR-IC2/2*/iFluor™ 670 Anti-human CD102 Antibody *CBR-IC2/2*
询价
MSK1 (phospho Ser212) 抗体-MSK1 (phospho Ser212) Antibody
￥22
MAGE Family Member B10 (MAGEB10) Antibody/MAGE Family Member B10 (MAGEB10) Antibody/MAGE Family Member B10 (MAGEB10) Antibody
询价
RPUSD1单克隆抗体 | RPUSD1 monoclonal antibody
询价
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Nuclear extract of human HL-60 cells was used as the immunogen for this Ku70 + Ku80 antibody.
- 保存条件：
Aliquot and Store at 2-8℃
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
小鼠
- 应用范围：
ICC, Flow, IF
- 抗体英文名：
Ku70 + Ku80 Antibody [KU729]
- 抗体名：
Ku70 + Ku80 Antibody [KU729]
- 规格：
100ug
Ku70 + Ku80 抗体 [KU729]，Ku70 + Ku80 Antibody [KU729]，Ku70 + Ku80 抗体 [KU729],Ku70 + Ku80 Antibody [KU729]
产品名称：Ku70 + Ku80 抗体 [KU729]-Ku70 + Ku80 Antibody [KU729]
产品货号：PSI-33-138-100ug
产品规格：100ug
背景资料：This antibody recognizes a dimer of two proteins of 70kDa (Ku70) and ~80kDa (Ku80), identified as two subunits of Ku. Antbody KU729 recognizes a conformational epitope of the Ku70 + Ku80 dimer, which is destroyed during Western blotting. The Ku70 + Ku80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
保存建议：Ku70 + Ku80 抗体 [KU729]-Ku70 + Ku80 Antibody [KU729]Aliquot and Store at 2-8℃
应用类型：ICC, Flow, IF
点击：Ku70 + Ku80 抗体 [KU729]-Ku70 + Ku80 Antibody [KU729]查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Mol Cell：杨薇等揭示 DNA-PK 的激活机制以及自磷酸化对 NHEJ 通路的重要作用
报道了 3.24 Å 的 apo-DNA-PKcs、3.9 Å DNA-PK 单体和 7.24 Å DNA-PK 二体等的冷冻电镜结构，DNA-PK 二聚化由 Ku80 的最靠近 C 端的 ⍺ 螺旋所介导，揭示了 NHEJ 通路初期 DNA 末端远端匹配的可能机制 [4]。 尽管如此，以上所有报道的结构都为抑制态，激酶结构域的激酶活性中心都处于封闭状态，无法解释 DNA-PKcs 是怎么结合 Ku70/80 和 DNA 末端以及怎么被它们激活的，且由于冷冻电镜 map 的局部分辨率不够高，无法
Proteomic Strategies: SILAC and 2D-DIGEPowerful Tool to Investigate Cellular Alterations
). After exposure to high-dose radiation, an immediate down-regulation is seen in the Ku70/Ku80 heterodimer and proliferating cell nuclear antigen (PCNA) proteins belonging to the NHEJ DNA repair pathway. Later time points show significant decrease in the expression
Detection of DNA-Dependent Protein Kinase in Extracts from Human and Rodent Cells
, Ku. Ku is composed of 70-kDa and approx 80-kDa subunits (called Ku70 and Ku80, respectively) and targets DNA-PKcs to ends of double-stranded DNA. DNA-PKcs is related by amino acid sequence to the phosphatidyl inositol kinase (PI-3 kinase) protein
技术资料暂无技术资料 索取技术资料
