PSTPIP1 抗体-PSTPIP1 Antibody

PSTPIP1 抗体，PSTPIP1 Antibody，PSTPIP1 抗体,PSTPIP1 Antibody

产品名称：PSTPIP1 抗体-PSTPIP1 Antibody

产品货号：PSI-19-323-100uL

产品规格：100uL

背景资料：This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.

保存建议：PSTPIP1 抗体-PSTPIP1 AntibodyStore at 4℃

应用类型：WB,Flow

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