RAG2 抗体-RAG2 Antibody

RAG2 抗体，RAG2 Antibody，RAG2 抗体,RAG2 Antibody

产品名称：RAG2 抗体-RAG2 Antibody

产品货号：PSI-14-455-50uL

产品规格：50uL

背景资料：This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

保存建议：RAG2 抗体-RAG2 AntibodyStore at -20℃

应用类型：WB

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