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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
N-RAS antibody was raised against a 15 amino acid peptide near the carboxy terminus of human N-RAS.<br>The immunogen is located within the last 50 amino acids of N-RAS.
- 保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
E, WB
- 抗体英文名:
N-RAS Antibody
- 抗体名:
N-RAS Antibody
- 规格:
0.02mg
N-RAS 抗体,N-RAS Antibody,N-RAS 抗体,N-RAS Antibody
产品名称:N-RAS 抗体-N-RAS Antibody
产品货号:PSI-7381-0.02mg
产品规格:0.02mg
背景资料:N-RAS Antibody: Activating mutations and overexpression of classical Ras subfamily members (N-RAS, H-RAS, and K-RAS) have been widely investigated as key events in the development of human cancers. The N-RAS protein shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. N-RAS, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
保存建议:N-RAS 抗体-N-RAS Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型:E, WB
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文献和实验Ras 信号通路 很多生长因子如EGF、PDGF、FGF等激活受体酪氨酸激酶后,通过中介分子可活化由原癌基因FaS编码的Ras蛋白 ,后者能进一步催化其底物蛋白的酪氨酸磷酸化反应,并引发蛋白磷酸化的级联反应,最终导致细胞的增殖效应。由于Ras蛋白为多种生长因子信号转导过程所共有,故把此信号转导途径称为Ras通路。 Ras蛋白是癌基因las的编码产物,人类有3种ras基因,即H―FaS、K―las和N―Fas,分布于不同染色体上,能编码蛋白质P21。所有的Ras―P21均有结合鸟
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In the field of therapeutic recombinant proteins, monoclonal antibodies (mAbs) have achieved a rising success with more than 30 mAbs that have reached the market in the past 20 years. From a structural standpoint, one of the most important
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