PEN2 抗体-PEN2 Antibody

PEN2 抗体，PEN2 Antibody，PEN2 抗体,PEN2 Antibody

产品名称：PEN2 抗体-PEN2 Antibody

产品货号：PSI-3979-0.02mg

产品规格：0.02mg

背景资料：PEN2 Antibody: PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease.

保存建议：PEN2 抗体-PEN2 Antibody stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E, WB, IF

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