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IL11RA 抗体-IL11RA Antibody
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
TLR5 antibody was raised against a peptide corresponding to 16 amino acids near the center of human TLR5.<br>The immunogen is located within amino acids 450 - 500 of TLR5.
- 保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
E, WB, IHC-P
- 抗体英文名:
TLR5 Antibody
- 抗体名:
TLR5 Antibody
- 规格:
0.02mg
TLR5 抗体,TLR5 Antibody,TLR5 抗体,TLR5 Antibody
产品名称:TLR5 抗体-TLR5 Antibody
产品货号:PSI-3647-0.02mg
产品规格:0.02mg
背景资料:TLR5 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-κB, leading to the activation of TNF-α and other cytokines. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires'disease and demonstrates the importance of TLR5 in the innate immune response.
保存建议:TLR5 抗体-TLR5 Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型:E, WB, IHC-P
点击:TLR5 抗体-TLR5 Antibody查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验在免疫反应方面,基于抗原的刺激在体内形成、并与抗原作特异性结合的蛋白质之总称。其化学实质是免疫球蛋白。抗体,按照抗原抗体反应的类型可分别称为沉淀素、凝集素、溶血素、溶菌素、抗毒素、中和抗体等,但这些并不等于有相应的不同抗体存在,一般多只表明抗体反应的多样性而已。抗体在血清中含量最多(体液抗体=humoral antibody);含有某特定抗体的血清称为抗血或免疫血清。
机体在抗原物质刺激下,由B细胞分化成的浆细胞所产生的、可与相应抗原发生特异性结合反应的免疫球蛋白。因为最初有人用电泳证明血清中抗体活性在γ球蛋白部分,故曾把抗体统称为两种(γ)球蛋白。后来证明,抗体并不都在γ区;而且位于γ区的球蛋白,也不一定都具有抗体活性。1964年,世界卫生组织举行专门会议,将具有抗体活性以及与抗体相关的球蛋白统称为免疫球蛋白(Ig)。如骨髓瘤蛋白,巨球蛋白血症、冷球蛋白血症等患者血清中存在的异常免疫球蛋白以及“正常人”天然存在的免疫
【进展|热点】Nature Immunology: TLR5+ LPDC在消化道细胞和体液免疫调节中的作用
的细胞。在这四种细胞中,只有CD11chiCD11bhiLPDCs高表达TLR5 mRNA,这个亚群DCs在flagellin刺激以后可以产生炎症因子IL-6、IL-12p40和IL-12p70而不是IL-23和IL-10,而CD11chiCD11bloLPDCs在用flagellin和LPS刺激后不均产生这些细胞因子。据此,可以认为,TLR5阳性的LPDC介导相关的固有免疫反应。 IgA是胃肠道中最丰富的免疫球蛋白,研究者认为TLR5阳性LPDC因表达ALDH1a2而可以生成RA,而后者可以促进
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