- $3865
- Leading Biology
- 美国
- PK54102M0
- 2025年07月07日
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- 详细信息
- 技术资料
- 保存条件：
Stable for 1 year at -4122°C or below from date of shipment.
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
200 ug
蛋白长度：A DNA sequence encoding the cynomolgus / rhesus MET (NP_001162100.1) (Met1-Thr932) was expressed five amino acids (DDDDK) the C-terminus. Cynomolgus and Rhesus MET sequences are identical.
性质：
表达系统：HEK293 Cells
种属：Cynomolgus, Rhesus
氨基酸序：Met1-Thr932
标签类型：No tag
分子量：The recombinant cynomolgus / rhesus MET comprises 914 amino acids and has a calculated molecular mass of 102.3 KDa. The apparent molecular mass of it is approximately 73-93 KDa in SDS-PAGE under reducing conditions.
活性：Immobilized Cynomolgus MET at 10 μg/ml (100 μl/well) can bind biotinylated Cynomolgus HGF (cat:PK54072M0), The ECof biotinylated Cynomolgus HGF (cat:PK54072M0) is 0.17-0.41 μg/ml.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：MET proto-oncogene, receptor tyrosine kinase
通用名：MET
蛋白序参考：NP_001162100.1
总结：Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
形式：Lyophilized
纯度：> 90 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：
性质：
表达系统：HEK293 Cells
种属：Cynomolgus, Rhesus
氨基酸序：Met1-Thr932
标签类型：No tag
分子量：The recombinant cynomolgus / rhesus MET comprises 914 amino acids and has a calculated molecular mass of 102.3 KDa. The apparent molecular mass of it is approximately 73-93 KDa in SDS-PAGE under reducing conditions.
活性：Immobilized Cynomolgus MET at 10 μg/ml (100 μl/well) can bind biotinylated Cynomolgus HGF (cat:PK54072M0), The ECof biotinylated Cynomolgus HGF (cat:PK54072M0) is 0.17-0.41 μg/ml.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：MET proto-oncogene, receptor tyrosine kinase
通用名：MET
蛋白序参考：NP_001162100.1
总结：Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
形式：Lyophilized
纯度：> 90 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：
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c-MET Protein, Cynomolgus, Rhesus, Recombinant
$3865
