PKC delta/PRKCD Protein, Mouse

蛋白长度：A DNA sequence encoding the mouse PRKCD isoform 1 (P28867-1) (Met 1-Ile 674) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

性质：

表达系统：Baculovirus-Insect Cells

种属：Mouse

氨基酸序：Met1-Ile674

标签类型：N-GST & His

分子量：The recombinant mouse PRKCD/GST chimera consists of 912 amino acids and has a calculated molecular mass of 106 kDa as estimated in SDS-PAGE under reducing conditions.

活性：Kinase activity untested

内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.

基因名称：protein kinase C, delta

通用名：PRKCD

蛋白序参考：

总结：PRKCD, a novel member of the pkc gene family, maps to human chromosome 3.Protein kinase C (PKC) delta (PRKCD) is a member of the novel PKC subfamily that regulates gene expression in bovine trophoblast cells. Protein kinase Cdelta (PRKCD) initiates this process by phosphorylating FBXO25 and HAX-1, thereby spatially directing nuclear FBXO25 to mitochondrial HAX-1.PRKCD may suppress macroautophagy/autophagy, a cytoprotective mechanism, to promote kidney tubule cell death during cisplatin treatment. Interestingly, PRKCD may do so by phosphorylating AKT, which further phosphorylates MTOR to repress ULK1.

形式：Liquid

纯度：> 80 % as determined by SDS-PAGE.

储存条件：Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Supplied as sterile 20mM Tris, 500mM NaCl, pH 8.0 Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.

别名：AI385711 Protein, Mouse; D14Ertd420e Protein, Mouse; Pkcd Protein, Mouse; PKCdelta Protein, Mouse; PKC[d] Protein, Mouse