- $15000
- Leading Biology
- 美国
- PH50492M4
- 2025年07月09日
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- 详细信息
- 技术资料
- 保存条件：
Stable for 1 year at -512°C or below from date of shipment.
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
1 mg
蛋白长度：A DNA sequence encoding the N-terminal segment (Met 1-Gln 118) of the extracellular domain of human ALK1 (NP_000011.2) pro-protein was fused with the Fc region of human IgG1 at the C-terminus.
性质：
表达系统：HEK293 Cells
种属：Human
氨基酸序：Met1-Gln118
标签类型：C-hFc
分子量：The mature recombinant human ALK1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer comprises 335 amino acids and has a predicted molecular mass of 37.4 kDa. As a result of glycosylation, the recombinant monomer migrates as an approximately 45-50 kDa protein in SDS-PAGE under reducing conditions.
活性：1. Measured by its ability to bind Human ENG-Fc (Cat:PH52077M4) in functional Elisa. 2. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. The EDfor this effect is typically 1-6 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：activin A receptor type II-like 1
通用名：ACVRL1
蛋白序参考：NP_000011.2
总结：Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
形式：Lyophilized
纯度：> 97 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：ACVRLK1 Protein, Human; ALK-1 Protein, Human; ALK1 Protein, Human; HHT Protein, Human; HHT2 Protein, Human; ORW2 Protein, Human; SKR3 Protein, Human; TSR-I Protein, Human
性质：
表达系统：HEK293 Cells
种属：Human
氨基酸序：Met1-Gln118
标签类型：C-hFc
分子量：The mature recombinant human ALK1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer comprises 335 amino acids and has a predicted molecular mass of 37.4 kDa. As a result of glycosylation, the recombinant monomer migrates as an approximately 45-50 kDa protein in SDS-PAGE under reducing conditions.
活性：1. Measured by its ability to bind Human ENG-Fc (Cat:PH52077M4) in functional Elisa. 2. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. The EDfor this effect is typically 1-6 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.
内毒素：< 1.0 EU per μg of the protein as determined by the LAL method.
基因名称：activin A receptor type II-like 1
通用名：ACVRL1
蛋白序参考：NP_000011.2
总结：Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
形式：Lyophilized
纯度：> 97 % as determined by SDS-PAGE.
储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
别名：ACVRLK1 Protein, Human; ALK-1 Protein, Human; ALK1 Protein, Human; HHT Protein, Human; HHT2 Protein, Human; ORW2 Protein, Human; SKR3 Protein, Human; TSR-I Protein, Human
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ALK-1 Protein, Human, Recombinant (hFc Tag)
$15000
