Podoplanin Protein, Human, Rec

蛋白长度：A DNA sequence encoding the human PDPN (Q86YL7) (Met1-Lys123) was expressed with a polyhistide tag at the C-terminus.

性质：

表达系统：HEK293 Cells

种属：Human

氨基酸序：Met1-Lys123

标签类型：C-His

分子量：The recombinant human PDPN consists of 112 amino acids and predicts a molecular mass of 11.78 kDa.

活性：Measured by its ability to bind recombinant CLEC1B-His/Biotin in a functional ELISA.

内毒素：< 1.0 EU per μg protein as determined by the LAL method.

基因名称：podoplanin

通用名：PDPN

蛋白序参考：

总结：Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.

形式：Lyophilized

纯度：> 95 % as determined by SDS-PAGE.

储存条件：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

储存溶液：Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

别名：AGGRUS Protein, Human; GP36 Protein, Human; Gp38 Protein, Human; GP40 Protein, Human; HT1A-1 Protein, Human; OTS8 Protein, Human; PA2.26 Protein, Human; T1A Protein, Human; T1A-2 Protein, Human; T1A2 Protein, Human; TI1A Protein, Human