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- Avidity Biosciences
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- 2025年08月03日
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维百奥生物特约代理Avidity Biosciences公司产品。
Avidity Biosciences公司位于美国加州La Jolla，是一家专门从事抗体寡核苷酸结合物（AOC™）技术开发的生物技术公司，此项技术结合了单抗组织选择性和寡核苷酸疗法的精确性，克服了寡核苷酸给药屏障。
Avidity Biosciences is a privately-held biotech company pioneering Antibody Oligonucleotide Conjugates (AOC™). AOCs combine the tissue selectivity of monoclonal antibodies and the precision of oligonucleotide-based therapeutics to overcome barriers to the delivery of oligonucleotides and target genetic drivers of disease.
Antibody oligonucleotide conjugate (AOC™) technology
Avidity’s antibody oligonucleotide conjugate (AOC™) technology utilizes antibodies to target cells and tissues of interest and facilitate the uptake and internalization of oligonucleotide payloads. By combining the cellular and tissue selectivity of antibodies with the selectivity and efficiency of oligo-based approaches, Avidity has demonstrated modulation of disease-related RNAs in diverse cell types and tissues including muscle, heart, liver, tumors and immune cells.
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文献和实验[1]为对蛋白质抗原、细菌、病毒等的复合抗原同抗体结合的强度间接测定所表示的尺度。将抗原抗体结合物稀释，或加入游离抗原时，从结合解离程度进行判断。 [2]也有指抗体亲和力的。
This chapter describes a modified enzyme-linked immunosorbent assay (ELISA) employing assay conditions that ensure specificity of antibody binding and favor detection primarily of high-avidity serum IgG antibodies to meningococcal serogroup C
Immunotherapy With CTL Restricted by Nonself MHC
that were identical in normal and tumor cells. Gene expression in normal tissues may result in tolerance of high avidity CTL, leaving behind low avidity CTL that cannot provide effective immunity against tumors expressing the relevant target antigens. In this chapter
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