DPPA2抗体（pAb）DPPA2 antibody (pA

DPPA2 and DPPA4 (developmental pluripotency associated 2 and 4) are small heterodimerizing nuclear proteins linked in the biological processes of transcription and transcription regulation. The encoded proteins have a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. The nuclear factor encoded by the gene is involved in the maintenance of pluripotency in stem cells and is found to be essential for embryogenesis. DPPA2 and DPPA4 are required to maintain H3K4me3 and H3K27me3 at important bivalent promoters depicted in pluripotent cells by low H3K4me3 levels and initiating but not elongating RNA polymerase II. This gene is thought to play an important role in tumor progression because when mutated it is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers.

Active Motif 简介：

Active Motif是由全球著名的生命技术公司，致力于向生命科学和药物研发的表观遗传领域提供技术领先、创新设计的试剂和整体解决方案。主要从事表观遗传领域产品和服务的研发及销售，产品涉及抗体、重组蛋白、试剂盒和超声仪器等。是全球最早、最著名的提供表观遗传学服务的公司之一，提供包括复杂及少量样本的ChIP-seq，ATAC-seq，CUT&RUN，CUT&Tag，MeDIP，RNA-seq等服务。