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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD275
- 级别:
CD275 (B7-H2, ICOSL) Antibody
- 目录编号:
CD275 (B7-H2, ICOSL) Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
CD275 (B7-H2, ICOSL) Antibody
- 抗体英文名:
anti-human CD275 (B7-H2, ICOSL) Antibody-PE
- 抗体名:
CD275 (B7-H2, ICOSL) Antibody
- 标记物:
PE
- 宿主:
小鼠
- 适应物种:
人
- 免疫原:
CD275 (B7-H2, ICOSL) Antibody
- 亚型:
CD275 (B7-H2, ICOSL) Antibody
- 形态:
CD275 (B7-H2, ICOSL) Antibody
- 应用范围:
FC
- 保存条件:
2-8℃
- 浓度:
CD275 (B7-H2, ICOSL) Antibody
- 规格:
25 tests/ 100 tests
| 规格: | 25 tests | 产品价格: | ¥1900.0 |
|---|---|---|---|
| 规格: | 100 tests | 产品价格: | ¥4200.0 |
Description :B7-H2, a member of the B7 family and the immunoglobulin superfamily, is a 40 kD protein alsoknown as B7RP-1, B7h, B7-H2, GL50 and ICOS Ligand. Human B7-H2 is expressed by Blymphocytes, activated monocytes/macrophages, and dendritic cells. B7-H2 binds to a CD28-like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed byactivated T cells. The interaction of ICOS with B7-H2 plays an important role in the T cellcostimulation pathway.
Verified Reactivity :Human
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :Human B7H2-mIg fusion protein
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation :The antibody was purified by affinity chromatography, and conjugated with PE under optimalconditions.
Concentration :Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :FC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser :Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
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文献和实验1. Kurosawa S, et al. 2003. Am. J. Respir. Cell Mol. Biol. 28:563.
Product Citations:
1. Sugawara E, et al. 2020. Autophagy. 1.323611111. PubMed
2. Lu Y, et al. 2020. Cell. 180(6):1081-1097. PubMed
3. Arenas EJ, et al. 2021. Nat Commun. 12:1237. PubMed
4. Sebina I, et al. 2016. PLoS Pathog. 12:e1005999. PubMed
5. O'Connor MH, et al. 2021. Commun Biol. 4:563. PubMed
6. Schatton T, et al. 2010. Cancer Res. 70:697. PubMed
7. Dianzani C, et al. 2010. J Immunol. 185:3970. PubMed
8. Siedlik J, et al. 2017. J Immunol Methods. 10.4049/jimmunol.1700003. PubMed
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机体免疫应答过程的复杂性和严格的调控性,是由多种免疫细胞和免疫分子共同参与完成的。而T淋巴细胞的活化,在免疫应答中扮演着相当重要的角色。研究表明,诱导T细胞的活化与增殖需要两种信号:一种是 TCR/CD3 与抗原提呈细胞(APCs)表面特异的 MHCⅡ 抗原肽复合物结合产生的特异性抗原刺激信号;另一种是非特异性协同刺激信号,由 APCs 表面的协同刺激分子和 T 细胞的相应受体相互作用后产生,其中 CD28/B7 是最为重要的协同刺激分子,能增加 IL-2 的产生,加速T细胞增殖,阻止细胞进入











