Purified 抗人 CD267 (TACI) 抗体

Purified anti-human CD267 (TACI) Antibody详细如下：

Description ：TACI, Transmembrane Activator CAML (calcium modulator and cyclophilin ligand) Interactor, isa 32 kD type III transmembrane protein. It belongs to TNF receptor superfamily, known asTNFRSF member 13B (TNFRSF13B) or CD267. TACI is expressed on B cells, predominantlyCD27+ memory B cells, and myeloma cells. TACI contains 2 cysteine-rich domains (CRDs) and1 potential N-linked glycosylation site in the extracellular domain. Recent studies, however,have shown that another shorter form (TACI_d2) of TACI exists wherein the N-terminal CRD isremoved by alternative splicing. TACI_d2 contains full affinity for its ligands. Several proteins(BAFF/BLys, APRIL, Syndecan-2) have been identified as TACI ligands. The interaction ofTACI with its ligands induces activation of the transcription factors NFAT, AP1, and NF-κ B.TACI also plays a crucial role in humoral immunity by negative regulation of B cell proliferationand survival.

Verified Reactivity ：Human

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：Human TACI transfected cells

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide

Preparation ：The antibody was purified by affinity chromatography.

Concentration ：0.5 mg/mL

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.

Application ：FC - Quality tested、Activation, WB - Reported in the literature, not verified in house

Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per millioncells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance foreach application.