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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
欣博盛生物
- 库存:
50
- 适应物种:
人
- 应用:
ELISA
- 检测范围:
3.31-200 ng/ml
- 规格:
96 wells
在制药和生物技术行业,人类治疗性抗体已日益成为早期药物发现和开发组合的常见组成部分。作为这些药物的临床前毒理学评估的一部分,它们在非人灵长类动物中进行常规测试,主要是在恒河猴或食蟹猴中。为了评估人抗体在猴血清中的药代动力学,有必要建立一种能够区分实验引入的人IgG和内源性猴IgG的分析方法。Cayman的Human Therapeutic IgG1 ELISA Kit是一种免疫测定法,可用于测量猴子或啮齿类动物血浆和血清中的人类IgG1,无需预先纯化样品。标准曲线的范围为3.13-200 ng/ml,LLOQ为3.13 ng/ml。该方法已在食蟹猴血清中得到验证。

产品详情:
货号:500910
产品名称:Human Therapeutic IgG1 ELISA Kit
检测范围:3.31-200 ng/ml
Lower Limit of Quantification:3.31 ng/ml
保存温度:4保质期:≥ 1 year
订购详情:
| 品牌 | 产品名称 | 产品货号 | 规格 | 报价 |
| Cayman | Human Therapeutic IgG1 ELISA Kit | 500910 | 96 wells | 8456元 (折扣价请联系在线客服) |
详情请咨询 Cayman 中国授权代理-欣博盛生物
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文献和实验consists of a cooperation between monocytes and cytophilic antibodies able to bind to the Fc receptors present on the monocyte surface. Thus human IgG1 and IgG3 are the main isotypes effective in ADCI, whereas IgG2, IgG4, and IgM are ineffective
Methods to Engineer and Identify IgG1 Variants with Improved FcRn Binding or Effector Function
site comprised of the heavy and light chain variable domains. In addition, the Fc portion of human or humanized IgG1 antibodies promotes long half-life through interaction with the recycling FcRn receptor and effects killing functions
In Vitro Immunogenicity Risk Assessment of Therapeutic Proteins in Preclinical Setting
therapeutics in the product development stages. Here, we attempted a mechanism-based in vitro study as screening tool to capture clinically observed antibody-based immune response against two representative therapeutic proteins: recombinant human Erythropoietin
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