Fire™ 750 抗人 CD340 (erbB2/HER-

Fire™ 750 anti-human CD340 (erbB2/HER-2) Antibody-APC详细如下：

Description ：CD340 is also known as HER2/erbB2, tyrosine kinase cell surface receptor HER2, oncogeneERBB2, and oncogene NGL, neuroblastoma- or glioblastoma-derived. It is a member of theepidermal growth factor receptor family of cell membrane tyrosine kinases containing a singletransmembrane domain and has an approximate molecular weight of 185 kD. CD340 containsthree furin repeats and two cheY homologous receiver domains in the extracellular region(ECR). The HER2/erbB2 protein is expressed on many tumor cells, including some breastcancers, lung adenocarcinoma, gastric cancer, ovarian cancer, gliblastoma, some c-ALL blastsand bone marrow mesenchymal stem cells. Although the erbB2/HER2 protein contains noligand binding domain, this protein interacts with other EGF receptor family members to form aheterodimer, stabilize ligand binding, and enhance kinase-mediated downstream signaling.CD340 has been shown to be involved in embryonic development and cancer progression; thisprotein is amplified in adenocarcinoma of the lung, some breast cancers, glioblastoma, gastriccancer, and ovarian carcinoma, where it functions as an oncogene. Overexpression of erbB2in breast cancers has been shown to confer Taxol resistance and is a therapeutic target in anumber of human cancers. The erbB2/HER-2 protein has been shown to interact with a largenumber of proteins, including SHC1, EGF receptorm, neuroregulin 1, c-Src, integrin β4, Grb2,Grb7, SOS1, caveolin 1, JAK2, PAK1, FAK, and β-catenin, among others. CD340 is extensivelymodified by tyrosine phosphorylation on multiple residues (Y1023, Y1139, Y1196, Y1221,Y1222, Y1248).

Verified Reactivity ：Human

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：NIH-3T3 transfected with human HER-2

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation ：The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 underoptimal conditions.

Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.

Application ：FC - Quality tested

Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.

* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 774 nm.

Excitation Laser ：Red Laser (633 nm)