Description :Caspase-8 is involved in the apoptosis mediated by CD95 and TNFR-1. It is suggested thatfollowing the triggering of apoptosis by CD95 or TNFR-1, the adaptor molecule FADD interactphysically with cytosolic caspase-8 and initiate the apoptotic cascade. The active caspase-8consists of two subunits of p18 and p10. This antibody should recognize the whole length ofhuman caspase-8 and some isofrms of lower MW.
Verified Reactivity :Human
Antibody Type :Monoclonal
Host Species :Rat
Immunogen :Full length caspase-8 fusion protein
Formulation :This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation :The antibody was purified by affinity chromatography
Concentration :0.5 mg/ml
Storage & Handling :Upon receipt, store between 2°C and 8°C.
Application :WB - Quality tested、IHC, ELISA - Reported in the literature, not verified in house
Recommended Usage :Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggestedworking dilution(s): Use 0.5-1 µg antibody per ml antibody dilution buffer for each mini-gel. It isrecommended that the reagent be titrated for optimal performance for each application.