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- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD1d (CD1.1, Ly-38)
- 级别:
CD1d (CD1.1, Ly-38) Antibody
- 目录编号:
CD1d (CD1.1, Ly-38) Antibody
- 克隆性:
单克隆
- 抗原来源:
大鼠
- 保质期:
CD1d (CD1.1, Ly-38) Antibody
- 抗体英文名:
Ultra-LEAF™ Purified anti-mouse CD1d (CD1.1, Ly-38) Antibody
- 抗体名:
CD1d (CD1.1, Ly-38) Antibody
- 标记物:
CD1d (CD1.1, Ly-38) Antibody
- 宿主:
大鼠
- 适应物种:
小鼠
- 免疫原:
CD1d (CD1.1, Ly-38) Antibody
- 亚型:
CD1d (CD1.1, Ly-38) Antibody
- 形态:
CD1d (CD1.1, Ly-38) Antibody
- 应用范围:
FC, Block, IHC, IP
- 保存条件:
2-8℃
- 浓度:
CD1d (CD1.1, Ly-38) Antibody
- 规格:
100 µg/1 mg
| 规格: | 100 µg | 产品价格: | ¥3000.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥12300.0 |
Description :CD1d, known as CD1.1 and Ly-38, is a 48 kD type I membrane glycoprotein with structuralsimilarities to MHC class I and is non-covalently associated with β2-microglobulin. In humans,CD1 family consists of group I proteins (CD1a, CD1b, and CD1c), group II (CD1d), and group III(CD1e). But CD1d is the only CD1 molecule has been found in mouse. Mouse CD1d has broadtissue distribution, and is found on leukocytes, dendritic cells, epithelial cells, and thymocytes.CD1d plays a role in non-peptide glycolipid antigen presentation to CD1d-restricted T cells. Ithas been shown that PKCδ is a critical regulator of CD1d-mediated antigen presentation.
Verified Reactivity :Mouse
Antibody Type :Monoclonal
Host Species :Rat
Immunogen :Mouse Cd1.1 cDNA-transfected RMA-S mouse T lymphoma
Formulation :0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxinlevel is < 0.01 EU/µg of the protein (< 0.001 ng/µg of the protein) as determined by the LAL test.
Preparation :The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Concentration :The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentrationand expiration, please enter the lot number in our Certificate of Analysis online tool.
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™solution contains no preservative; handle under aseptic conditions.
Application :FC - Quality tested、IHC, IP, Block - Reported in the literature, not verified in house
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per millioncells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance foreach application.
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文献和实验1. Fischer K, et al. 2004. P. Natl. Acad. Sci. USA 101:10685. (Block)
2. Brozovic S, et al. 2004. Nat. Med. 10:535.
3. Brossay L, et al. 1997. J. Immunol.. 159:1216. (Block)
4. Jiang J, et al. 2012. PLoS One. 7:47487. PubMed
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单克隆抗体制备技术Burnef(1957)细胞系群选择学说(clonal selection theory)认为,每一个淋巴细胞只具备单一的受体特异性,受到刺激后,只能产生一种针对其可识别的抗原决定簇的抗体;抗体的多样性是由机体遗传存在着能与众多抗原决定簇起反应的淋巴细胞系而决定的;一个祖先抗体形成细胞分裂繁殖而成的细胞系(克隆clone或无性繁殖细胞系)产生的抗体具有完全相同的分子结构和性状;从一个克隆细胞系产生的抗体,称单克隆抗体(monoclonal antibody,McAb);一个
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