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- Sino Biological
- 北京
- 40589-V08H58
- 2026年01月26日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant SARS-CoV-2 BA.2.86 Spike S1+S2 trimer Protein (ECD, His Tag)
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
100.00 µg
重组新冠病毒 BA.2.86 Spike S1+S2 trimer 蛋白 (ECD, His 标签)（产品说明）
蛋白名称：Recombinant SARS-CoV-2 BA.2.86 Spike S1+S2 trimer Protein (ECD, His Tag)
蛋白构建：A DNA sequence encoding the SARS-CoV-2 (BA.2.86) Spike S1+S2 (YP_009724390.1, with mutations T19I, R21T, L24del, P25del, P26del, A27S, S50L, H69del, V70del, ins16MPLF, P1143L, V127F, G142D, Y144del, F157S, R158G, N211del, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483del, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, I670V, N679K, P681R, N764K, D796Y, F817P, A892P, A899P, S939F, A942P, Q954H, N969K, K986P, V987P and furin cleavage site mutants) expressed with the bacteriophage T4 fibritin and a polyhistidine tag at the C-terminus. The mutations were identified in the SARS-CoV-2 variant (known as variant BA.2.86).
表达宿主：HEK293 Cells
蛋白纯度：≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ≥ 95 % as determined by SEC-MALS.
蛋白活性：Immobilized Recombinant Human ACE2 / Angiotensin-Converting Enzyme 2 Protein (Fc Tag) (Cat: 10108-H05H) at 2 μg/mL (100 μL/well) can bind Recombinant SARS-CoV-2 BA.2.86 Spike S1+S2 trimer Protein (ECD, His Tag) (Cat: 40589-V08H58), the EC50 is 3.6-12 ng/mL.
蛋白内毒素：< 1.0 EU per μg protein as determined by the LAL method.
预测N端：Val 16
蛋白分子量：The recombinant SARS-CoV-2 (BA.2.86) Spike S1+S2 consists of 1229 amino acids and predicts a molecular mass of 136.75 kDa.
蛋白NP号：YP_009724390.1
蛋白氨基酸序列：Met1-Gln1208
蛋白标签：C-His
蛋白保存条件：-20℃ to -80℃
蛋白名称：Recombinant SARS-CoV-2 BA.2.86 Spike S1+S2 trimer Protein (ECD, His Tag)
蛋白构建：A DNA sequence encoding the SARS-CoV-2 (BA.2.86) Spike S1+S2 (YP_009724390.1, with mutations T19I, R21T, L24del, P25del, P26del, A27S, S50L, H69del, V70del, ins16MPLF, P1143L, V127F, G142D, Y144del, F157S, R158G, N211del, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483del, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, I670V, N679K, P681R, N764K, D796Y, F817P, A892P, A899P, S939F, A942P, Q954H, N969K, K986P, V987P and furin cleavage site mutants) expressed with the bacteriophage T4 fibritin and a polyhistidine tag at the C-terminus. The mutations were identified in the SARS-CoV-2 variant (known as variant BA.2.86).
表达宿主：HEK293 Cells
蛋白纯度：≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ≥ 95 % as determined by SEC-MALS.
蛋白活性：Immobilized Recombinant Human ACE2 / Angiotensin-Converting Enzyme 2 Protein (Fc Tag) (Cat: 10108-H05H) at 2 μg/mL (100 μL/well) can bind Recombinant SARS-CoV-2 BA.2.86 Spike S1+S2 trimer Protein (ECD, His Tag) (Cat: 40589-V08H58), the EC50 is 3.6-12 ng/mL.
蛋白内毒素：< 1.0 EU per μg protein as determined by the LAL method.
预测N端：Val 16
蛋白分子量：The recombinant SARS-CoV-2 (BA.2.86) Spike S1+S2 consists of 1229 amino acids and predicts a molecular mass of 136.75 kDa.
蛋白NP号：YP_009724390.1
蛋白氨基酸序列：Met1-Gln1208
蛋白标签：C-His
蛋白保存条件：-20℃ to -80℃
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文献和实验该产品被引用文献
1, Izadi, A; et al. Protective Non-neutralizing anti-N-terminal Domain mAb Maintains Fc-mediated Function against SARS-COV-2 Variants up to BA.2.86-JN.1 with Superfluous In Vivo Protection against JN.1 Due to Attenuated Virulence. Journal of immunology (Baltimore, Md. : 1950), PMID: 39018495
相关实验
全球首次！分离的新冠病毒中和抗体，还可同时抗 SARS 病毒
抗原表位，为预防和治疗新型冠状病毒肺炎 COVID- 19 提供了可能。图片来源：bioRxiv通常，冠状病毒中和抗体主要靶向介导进入宿主细胞的病毒表面三聚体刺突糖蛋白（Spike Glycoproteins，S 蛋白）。S 蛋白具有介导细胞附着的两个功能亚基：负责受体识别的 S1 亚基（存在四个核心结构域 S1 A/B/C/D）以及促使病毒与细胞膜融合的 S2 亚基。强大的中和抗体通常会靶向 S1 中的受体相互作用位点，从而使受体相互作用失效。之前的研究表明，SARS-CoV- 2 和 SARS-CoV
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Sino Biological 重组新冠病毒BA.2.86 Spike S1+S2 trimer蛋白 HEK293表达 His标签 高纯度
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