Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
供应商:
爱必信(上海)生物科技有限公司
保存条件:
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
规格:
10ug/50ug
规格:
10ug
产品价格:
¥750.0
规格:
50ug
产品价格:
¥2500.0
概述
种属
Human
来源
E.coli
分子量
15-16kDa (Reducing)
外观
Lyophilized powder
形态
Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, 1mM EDTA, pH8.0
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存/保存方法
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
靶标
背景说明
Interleukin 4(IL4) was first identified as a helper T cell product with the capacity to co-stimulate B cell growth in vitro. IL-4 also can rescue B-cells from apoptosis, enhancing their survival, and is responsible for immunoglobulin isotype switching to IgG1 and IgE. The effect of IL-4 signaling is mediated through the IL-4 receptor alpha chain (IL-4Rα). Upon binding to its ligand, IL-4Rα dimerizes either with the common gamma chain (γc) to produce the type-1 signaling complex located mainly on hematopoietic cells, or with the IL-13 receptor alpha 1 (IL-13Rα1) to produce the type-2 complex, which is expressed also on non-hematopoietic cells. The type-1 signaling complex is critical for Th2-skewing of T cells and the development of alternatively activated macrophages (AAMΦs), while the type-2 complex plays a role in non-hematopoietic responses to IL-4 and IL-13.