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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现货
- 英文名：
Recombinant Human IL-4 Protein
- 保质期：
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
- 供应商：
爱必信(上海)生物科技有限公司
- 保存条件：
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
- 规格：
10ug/50ug
| 规格： | 10ug | 产品价格： | ￥750.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2500.0 |
| 概述 | |
| 种属 | Human |
| 来源 | E.coli |
| 分子量 | 15-16kDa (Reducing) |
| 外观 | Lyophilized powder |
| 形态 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, 1mM EDTA, pH8.0 |
| 性能 | |
| 序列 | HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS |
| 纯度 | ＞95% by SDS-PAGE |
| 内毒素水平 | <0.1EU/ug |
| 活性 | <0.2ng/ml |
| 溶解方法 | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| 储存/保存方法 | Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles. |
| 靶标 | |
| 背景说明 | Interleukin 4(IL4) was first identified as a helper T cell product with the capacity to co-stimulate B cell growth in vitro. IL-4 also can rescue B-cells from apoptosis, enhancing their survival, and is responsible for immunoglobulin isotype switching to IgG1 and IgE. The effect of IL-4 signaling is mediated through the IL-4 receptor alpha chain (IL-4Rα). Upon binding to its ligand, IL-4Rα dimerizes either with the common gamma chain (γc) to produce the type-1 signaling complex located mainly on hematopoietic cells, or with the IL-13 receptor alpha 1 (IL-13Rα1) to produce the type-2 complex, which is expressed also on non-hematopoietic cells. The type-1 signaling complex is critical for Th2-skewing of T cells and the development of alternatively activated macrophages (AAMΦs), while the type-2 complex plays a role in non-hematopoietic responses to IL-4 and IL-13.
|
| Accession | P05112 |
实验结果图：
1μg (R: reducing conditions, N: non-reducing conditions).
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