- ￥4500
- 齐源
- 678502
- 国产/进口
- 2025年07月14日
- WB
- 小鼠
- 人
6 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
Cathepsin D
- 级别：
Cathepsin D Antibody
- 目录编号：
Cathepsin D Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
Cathepsin D Antibody
- 抗体英文名：
Purified anti-Cathepsin D Antibody
- 抗体名：
Cathepsin D Antibody
- 标记物：
Cathepsin D Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
Cathepsin D Antibody
- 亚型：
Cathepsin D Antibody
- 形态：
Cathepsin D Antibody
- 应用范围：
WB
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
100 ug
Purified anti-Cathepsin D Antibody详细如下：
Description ：Cathepsin D (CTSD) is a major lysosomal aspartic endoproteinase. It is active in acidicconditions with a pH range from 3.5 to 5.0, and its activity is inhibited by pepstatin A. CTSD isinvolved in lysosomal protein turnover and many other cellular processes. CTSD participates inthe resolution of inflammation by initiating the apoptotic program in neutrophils. CTSD isreleased from neutrophil azurophilic granules during the initial stage of apoptosis, which leadsto death receptor-independent activation of caspase-8. CTSD induces apoptosis in other cellsas well. In T cells, CTSD activates Bax, which leads to the release of mitochondrial apoptosisinducing factor (AIF), and subsequently induces an early caspase-independent apoptoticphenotype. CTSD also takes part in the release of cytochrome C from the mitochondria andactivation of caspases in fibroblast apoptosis, which is induced by staurosporine. In addition,CTSD participates in cell proliferation, and it also increases proliferation and metastaticpotential of many cancer cell lines. Overexpression of CTSD has been reported in manydifferent cancers including malignant glioma, melanoma, breast, ovarian, endometrial, andbladder cancer. CTSD is also involved in neurodegenerative diseases. CTSD knockout micedie shortly after birth and display some neurodegeneration phenotypes. Mutations of CTSDcause congenital neuronal ceroid lipofuscinosis in humans and animals. CTSD cleaves theamyloid precursor protein and may play a role in Alzheimer’s disease. CTSD-deficiency hasalso been associated with Parkinson disease. Like CTSB and CTSL, CTSD functions outsidethe cells and is able to cleave extracellular matrix proteins including collagen, fibronectin,proteoglycans, and laminin.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Partial human cathepsin D recombinant protein (21-412 a.a.) expressed in 293E cells.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.
Application ：WB - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titratedfor optimal performance for each application.
Description ：Cathepsin D (CTSD) is a major lysosomal aspartic endoproteinase. It is active in acidicconditions with a pH range from 3.5 to 5.0, and its activity is inhibited by pepstatin A. CTSD isinvolved in lysosomal protein turnover and many other cellular processes. CTSD participates inthe resolution of inflammation by initiating the apoptotic program in neutrophils. CTSD isreleased from neutrophil azurophilic granules during the initial stage of apoptosis, which leadsto death receptor-independent activation of caspase-8. CTSD induces apoptosis in other cellsas well. In T cells, CTSD activates Bax, which leads to the release of mitochondrial apoptosisinducing factor (AIF), and subsequently induces an early caspase-independent apoptoticphenotype. CTSD also takes part in the release of cytochrome C from the mitochondria andactivation of caspases in fibroblast apoptosis, which is induced by staurosporine. In addition,CTSD participates in cell proliferation, and it also increases proliferation and metastaticpotential of many cancer cell lines. Overexpression of CTSD has been reported in manydifferent cancers including malignant glioma, melanoma, breast, ovarian, endometrial, andbladder cancer. CTSD is also involved in neurodegenerative diseases. CTSD knockout micedie shortly after birth and display some neurodegeneration phenotypes. Mutations of CTSDcause congenital neuronal ceroid lipofuscinosis in humans and animals. CTSD cleaves theamyloid precursor protein and may play a role in Alzheimer’s disease. CTSD-deficiency hasalso been associated with Parkinson disease. Like CTSB and CTSL, CTSD functions outsidethe cells and is able to cleave extracellular matrix proteins including collagen, fibronectin,proteoglycans, and laminin.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Partial human cathepsin D recombinant protein (21-412 a.a.) expressed in 293E cells.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.
Application ：WB - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titratedfor optimal performance for each application.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
Purified 抗组织蛋白酶 D 抗体
￥4500
