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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
Ly-49C/F/I/H
- 级别：
Ly-49C/F/I/H Antibody
- 目录编号：
Ly-49C/F/I/H Antibody
- 克隆性：
单克隆
- 抗原来源：
仓鼠
- 保质期：
Ly-49C/F/I/H Antibody
- 抗体英文名：
anti-mouse Ly-49C/F/I/H Antibody-PE
- 抗体名：
Ly-49C/F/I/H Antibody
- 标记物：
PE
- 宿主：
仓鼠
- 适应物种：
小鼠
- 免疫原：
Ly-49C/F/I/H Antibody
- 亚型：
Ly-49C/F/I/H Antibody
- 形态：
Ly-49C/F/I/H Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
0.2 mg/ml
- 规格：
50 µg/200 µg
| 规格： | 50 µg | 产品价格： | ￥1800.0 |
|---|---|---|---|
| 规格： | 200 µg | 产品价格： | ￥5600.0 |
anti-mouse Ly-49C/F/I/H Antibody-PE详细如下：
Description ：The 14B11 antibody reacts with a common epitope of Ly-49C/F/I/H family members also knownas Ly-49 inhibitory receptors C, F, and I and activating receptor H. It does not react with otherLy-49 members (i.e., Ly-49A, B, D, and G). Ly-49 is a type-II transmembrane, disulfide-linkedhomodimer with C-type lectin extracellular domains that binds to MHC class I. Ly-49C/F/I/H isexpressed on a subset of NK cells, NK-T cells and some CD8 cells. Ly-49C/F/I, like othermembers of this family, inhibits NK cell activation through the recognition and interaction ofcertain MHC class I haplotypes on potential target cells. Ly-49C, Ly-49F, and Ly-49I contain anITIM motif in their cytoplasmic tails, while Ly-49H lacks ITIM. Ly-49H is encoded by the Cmv1rgene, which promotes resistance to infection by mouse cytomegalovirus (CMV). BALB/c miceare reported to lack the Ly-49H and Ly-49I receptors. The 14B11 antibody, when bound to NKcells, is capable of inducing redirected cell lysis and blocking NK cell effector function.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Syrian Hamster
Immunogen ：IL-2-activated killer cells (LAK) from C57BL/6 mice
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography, and conjugated with PE under optimalconditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10 cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
Description ：The 14B11 antibody reacts with a common epitope of Ly-49C/F/I/H family members also knownas Ly-49 inhibitory receptors C, F, and I and activating receptor H. It does not react with otherLy-49 members (i.e., Ly-49A, B, D, and G). Ly-49 is a type-II transmembrane, disulfide-linkedhomodimer with C-type lectin extracellular domains that binds to MHC class I. Ly-49C/F/I/H isexpressed on a subset of NK cells, NK-T cells and some CD8 cells. Ly-49C/F/I, like othermembers of this family, inhibits NK cell activation through the recognition and interaction ofcertain MHC class I haplotypes on potential target cells. Ly-49C, Ly-49F, and Ly-49I contain anITIM motif in their cytoplasmic tails, while Ly-49H lacks ITIM. Ly-49H is encoded by the Cmv1rgene, which promotes resistance to infection by mouse cytomegalovirus (CMV). BALB/c miceare reported to lack the Ly-49H and Ly-49I receptors. The 14B11 antibody, when bound to NKcells, is capable of inducing redirected cell lysis and blocking NK cell effector function.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Syrian Hamster
Immunogen ：IL-2-activated killer cells (LAK) from C57BL/6 mice
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography, and conjugated with PE under optimalconditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10 cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
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文献和实验该产品被引用文献
Application References(PubMed link indicatesBioLegend citation)：
1. Corral L, et al. 1999. Hybridoma 18:359.
2. Hanke T, et al. 1999. Immunity 11:67.
Product Citations：
1. Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed
1. Corral L, et al. 1999. Hybridoma 18:359.
2. Hanke T, et al. 1999. Immunity 11:67.
Product Citations：
1. Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed
文献支持
抗小鼠Ly-49C/F/I/H 荧光标记PE 抗体
￥1800 - 5600
