Description :IRF1 is the first identified member of the interferon regulatory transcription factor family. Itsexpression is induced in response to pathogen infection or the stimulation of several cytokines,including type I and II IFN, IL-1, IL-6, and TNF-α. Upon stimulation, IRF1 is transcriptionallyactivated by STAT1 and NFκB transcription factors via the GAS (interferon-gamma-activatedsequence) element in the IRF1 promoter. IRF1 plays important roles in mediating immuneresponse during infection and development of T cells and NK cells. In addition to theimmunomodulatory functions, IRF1 has also shown to be involved in the regulation of cell cycleprogression, tumor suppression, and apoptosis. IRF1-mediated transcription can be repressedby IRF2 through competing for the same binding region on the promoters.
Verified Reactivity :Human, Mouse
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :Partial human IRF1 recombinant protein (147-325 a.a.)
Formulation :This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation :Affinity purified.
Concentration :0.5 mg/mL
Storage & Handling :Upon receipt, store undiluted at 4°C.
Application :WB - Quality tested、ICC, IP - Verified
Recommended Usage :Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.5 - 2.0 µg per mL. For immunoprecipitation, the suggested useof this reagent is 2.0 - 10 μg per mL. It is recommended that the reagent be titrated for optimalperformance for each application.