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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD223
- 级别：
CD223 (LAG-3) Antibody
- 目录编号：
CD223 (LAG-3) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
CD223 (LAG-3) Antibody
- 抗体英文名：
TotalSeq™-C0152 anti-human CD223 (LAG-3) Antibody
- 抗体名：
CD223 (LAG-3) Antibody
- 标记物：
CD223 (LAG-3) Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
CD223 (LAG-3) Antibody
- 亚型：
CD223 (LAG-3) Antibody
- 形态：
CD223 (LAG-3) Antibody
- 应用范围：
PG
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
10 µg
TotalSeq™-C0152 anti-human CD223 (LAG-3) Antibody详细如下：
Description ：CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved inT-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells(NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated Tcells in acute conditions but high expression is maintained under tolerizing conditions. CD223deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverseexhausted phenotypes, improve tumor rejection, and control viral load.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Human LAG-3 transfected cells.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 1 mM EDTA.
Preparation The antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer underoptimal conditions.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application ：PG - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis and the oligomer sequence is confirmed by sequencing. TotalSeq™-C antibodies arecompatible with 10x Genomics Chromium Single Cell Immune Profiling Solution.
To maximize performance, it is strongly recommended that the reagent be titrated for eachapplication, and that you centrifuge the antibody dilution before adding to the cells at 14,000xg at 2- 8°C for 10 minutes. Carefully pipette out the liquid avoiding the bottom of the tube and add to thecell suspension. For Proteogenomics analysis, the suggested starting amount of this reagent fortitration is ≤ 1.0 µg per million cells in 100 µL volume. Refer to the corresponding TotalSeq™protocol for specific staining instructions.
Description ：CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved inT-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells(NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated Tcells in acute conditions but high expression is maintained under tolerizing conditions. CD223deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverseexhausted phenotypes, improve tumor rejection, and control viral load.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Human LAG-3 transfected cells.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 1 mM EDTA.
Preparation The antibody was purified by chromatography and conjugated with TotalSeq™-C oligomer underoptimal conditions.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application ：PG - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis and the oligomer sequence is confirmed by sequencing. TotalSeq™-C antibodies arecompatible with 10x Genomics Chromium Single Cell Immune Profiling Solution.
To maximize performance, it is strongly recommended that the reagent be titrated for eachapplication, and that you centrifuge the antibody dilution before adding to the cells at 14,000xg at 2- 8°C for 10 minutes. Carefully pipette out the liquid avoiding the bottom of the tube and add to thecell suspension. For Proteogenomics analysis, the suggested starting amount of this reagent fortitration is ≤ 1.0 µg per million cells in 100 µL volume. Refer to the corresponding TotalSeq™protocol for specific staining instructions.
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文献和实验该产品被引用文献
Product Citations：
1. Bachireddy P, et al. 2021. Cell Rep. 37:109992. PubMed
2. Sokal A, et al. 2021. Cell. 184(5):1201-1213.e14. PubMed
1. Bachireddy P, et al. 2021. Cell Rep. 37:109992. PubMed
2. Sokal A, et al. 2021. Cell. 184(5):1201-1213.e14. PubMed
文献支持
TotalSeq™-C0152 抗人 CD223 (LAG-3) 抗体
￥6500
