Description :B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs toTNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3(BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset.BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI andBCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and playspredominant roles in B-cell maturation and survival as well as costimulates T cell activation andproliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulatesBAFF-R-mediated NF-κB activation.
Preparation :The antibody was purified by affinity chromatography.
Concentration :0.5 mg/ml
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C.
Application :FC - Quality tested、IHC-P - Verified
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cellsin 100 µl volume. For immunohistochemical staining on formalin-fixed paraffin-embedded tissuesections, the suggested use of this reagent is 5.0 - 10 µg per ml. It is recommended that thereagent be titrated for optimal performance for each application.