抗ATM磷酸（Ser1981）荧光标记PE 抗体

anti-ATM Phospho (Ser1981) Antibody-PE详细如下：

Description ：Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cellcycle checkpoints and DNA repair. ATM is held inactive in unirradiated cells as a dimer orhigher-order multimer. Cellular irradiation induces rapid intermolecular autophosphorylation ofserine 1981 that causes dimer dissociation and initiates cellular ATM kinase activity. ATMkinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, andDNA repair, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2,checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. Mutations in thecorresponding ATM gene result in ataxia telangiectasia (AT), an autosomal recessive diseasecharacterized by uncoordinated muscle movement and neurodegeneration. Cells from ATpatients display defective DNA damage-induced checkpoint activation, sensitivity to radiation,and a higher frequency of chromosome breakage.

Verified Reactivity ：Human, Mouse
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：KLH conjugated synthetic peptide SLAFEEGSpQSTTISS
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE under optimalconditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.

Application ：ICFC - Quality tested

Recommended Usage： Each lot of this antibody is quality control tested by intracellular immunofluorescent staining withflow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimalperformance for each application.

Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)