Recombinant Anti-Clusterin Antibody, Rabbit Monoclonal 产品信息
产品名称Recombinant Anti-Clusterin Antibody, Rabbit Monoclonal
经验证的应用IHC-P (FAQProtocol)
交叉反应Reacts with: Human
特异性Human Clusterin
Has cross-reactivity in ELISA with
Mouse CLU
免疫原Recombinant Human Clusterin / Apolipoprotein J / Apo-J / CLU protein (Catalog#11297-H08H)
制备方法This antibody was obtained from a rabbit immunized with purified, recombinant Human Clusterin / Apolipoprotein J / Apo-J / CLU (rh Clusterin / Apolipoprotein J / Apo-J / CLU; Catalog#11297-H08H; NP_001822.2; Met1-Glu501).
来源Monoclonal Rabbit IgG Clone #210
纯化Protein A
缓冲液0.2 μm filtered solution in PBS
偶联物Unconjugated
状态Liquid
运输方式This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Recombinant Anti-Clusterin Antibody, Rabbit Monoclonal 经验证的应用
应用 推荐稀释比/用量
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Immunochemical staining of human CLU in human pancreas with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human CLU in human ovarian cancer with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human CLU in human appendix with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Recombinant Anti-Clusterin Antibody, Rabbit Monoclonal: 别称
Anti-AAG4 Antibody; Anti-APO-J Antibody; Anti-APOJ Antibody; Anti-CLI Antibody; Anti-CLU1 Antibody; Anti-CLU2 Antibody; Anti-KUB1 Antibody; Anti-NA1/NA2 Antibody; Anti-SGP-2 Antibody; Anti-SGP2 Antibody; Anti-SP-40 Antibody; Anti-TRPM-2 Antibody; Anti-TRPM2 Antibody
Clusterin 背景信息
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.
全称
clusterin
1, Wang, X; et al. Clusterin role in hepatocellular carcinoma patients treated with oxaliplatin Short title: CLU in HCC. portlandpress.com
2, Wang, X; et al. Clusterin role in hepatocellular carcinoma patients treated with oxaliplatin. Biosci. Rep., Pubmed: 32039450