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- 2025年07月09日
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Boronic Acid Compound Library
MCE 国际站：Boronic Acid Compound Library
Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity.MCE designs a unique collection of 14 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.
Description & Advantages:
• A unique collection of 14 boronic acid compounds for high throughput screening (HTS) and high content screening (HCS).
• A useful tool for cancer and other diseases research.
• Structurally diverse, medicinally active and cell permeable.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.
• More detailed compound information with structure, IC50, and other chemical & biological data.
• High purity and quality validated by NMR and LC/MS.
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文献和实验Specificity Profiling of Protein‐Binding Domains Using One‐Bead‐One‐Compound Peptide Libraries
Basic Protocol 1: Split‐and‐Pool Synthesis of One‐Bead‐One‐Compound Libraries Alternate Protocol 1: Synthesis of an Inverted Peptide Library Basic Protocol 2: Chemical Labeling of Proteins
Compound library HCVcc (stock titer ≥3.25 × 104 ; see protocol 3 and 2) FRET lysis buffer (see recipe ), prechilled to 4°
of Chemical Physics,Chinese Academy of Sciences, Dalian 116023） Abstract A boronic acidsubstituted silica was synthesized by using a γglycidoxypropyltrimethoxysilane as the spacer arm and using a 3amino4nitrobenzeneboronic acid as the ligand. The 3amino
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