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- MedChemExpress(MCE)
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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
3031078-90-4
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥1440.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥3600.0 |
| 规格： | 10 mg | 产品价格： | ￥5850.0 |
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PROTAC Hsp90α degrader 1
MCE 国际站：PROTAC Hsp90α degrader 1
产品活性：PROTAC Hsp90α degrader 1 (Compound X10g) 是一种选择性 PROTAC Hsp90α 降解剂。PROTAC Hsp90α degrader 1 可用于乳腺癌研究。PROTAC Hsp90α degrader 1 抑制 MDA-MB-231、MDA-MB-468、MCF-7、MX-1 细胞增殖 的 IC50s 分别为 51.48 μM、16.46 μM、8.93 μM、11.95 μM。
研究领域：PROTAC | Metabolic Enzyme/Protease | Cell Cycle/DNA Damage
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文献和实验Detecting HSP90 Phosphorylation
Heat-shock protein 90 (HSP90 ) is an essential molecular chaperone in eukaryotes. It is important for chaperoning proteins that are important determinants of multistep carcinogenesis. HSP90 ’s ATPase activity is associated with its chaperone
Assays for HSP90 and Inhibitors
The molecular chaperone HSP90 is currently under investigation as a promising target for anticancer drug discovery. It constitutes 1–2% of total cellular protein and is present in the cell as a dimer in association with a number
Hsp90 and Client Protein Maturation
Heat-shock protein 90 (Hsp90) is a molecular chaperone that assists in the maturation of a limited set of substrate proteins that are collectively referred to as clients. The majority of identified Hsp90 clients are involved in signal
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