Topoisomerase IIα-IN-5,3037545

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Topoisomerase IIα-IN-5

CAS No. :

MCE 国际站：Topoisomerase IIα-IN-5

产品活性：Topoisomerase IIα-IN-5 是一种拓扑异构酶 II (topo II) α 催化抑制剂。Topoisomerase IIα-IN-5 插入 DNA 并与 DNA 小槽结合。Topoisomerase IIα-IN-5 表现出比 Etoposide (HY-13629) 更好的疗效和更小的遗传毒性。

研究领域：Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：Topoisomerase  |  Apoptosis

In Vitro: Topoisomerase IIα-IN-5 (compound 6) (5 μM, 10 μM, and 20 μM; 10 d) inhibits colony formation of DU145 cells.
Topoisomerase IIα-IN-5 (1 μM and 10 μM; 72 h) shows antiproliferative against DU145 cells.
Topoisomerase IIα-IN-5 has cytotoxicity against DU145, HCT15, and T47D cells with IC₅₀s of 0.13 μM, 9.25 μM, and 0.53 μM, respectively.
Topoisomerase IIα-IN-5 (200 μM) interacts with a DNA double helix.
Topoisomerase IIα-IN-5 (20 μM; 24 h) induces G2 cell cycle arrest and apoptosis in CRPC cells.

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