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- 2025年12月05日
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Topoisomerase IIα-IN-5
MCE 国际站：Topoisomerase IIα-IN-5
产品活性：Topoisomerase IIα-IN-5 是一种拓扑异构酶 II (topo II) α 催化抑制剂。Topoisomerase IIα-IN-5 插入 DNA 并与 DNA 小槽结合。Topoisomerase IIα-IN-5 表现出比 Etoposide (HY-13629) 更好的疗效和更小的遗传毒性。
研究领域：Cell Cycle/DNA Damage | Apoptosis
作用靶点：Topoisomerase | Apoptosis
In Vitro: Topoisomerase IIα-IN-5 (compound 6) (5 μM, 10 μM, and 20 μM; 10 d) inhibits colony formation of DU145 cells.
Topoisomerase IIα-IN-5 (1 μM and 10 μM; 72 h) shows antiproliferative against DU145 cells.
Topoisomerase IIα-IN-5 has cytotoxicity against DU145, HCT15, and T47D cells with IC50s of 0.13 μM, 9.25 μM, and 0.53 μM, respectively.
Topoisomerase IIα-IN-5 (200 μM) interacts with a DNA double helix.
Topoisomerase IIα-IN-5 (20 μM; 24 h) induces G2 cell cycle arrest and apoptosis in CRPC cells.
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文献和实验Topoisomerase I and II Activity Assays
DNA topoisomerases I and II (top1 and top2, respectively) are ubiquitous enzymes that play an essential role in transcription, replication, chromosome segregation, and DNA repair. The basic enzymatic reaction of topoisomerases
Assaying Topoisomerase II Checkpoints in Yeast
Topoisomerase II activity is crucial to maintain genome stability through the removal of catenanes in the DNA formed during DNA replication and scaffolding the mitotic chromosome. Perturbed Topo II activity causes defects in chromosome
Purification of DNA Topoisomerase I from Human Placenta
DNA topoisomerase I (topo I) has been firmly established as the molecular target of the camptothecin group of anticancer drugs. These drugs include camptothecin, topotecan, 9-amino-camptothecin, and irinotecan
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