BioLegend 908303 PE anti-FOLR1

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BioLegend 908303 PE anti-FOLR1 (Folate Binding Protein)
产品简介：
产品品牌：BioLegend
产品货号：908303
产品名称：BioLegend 908303 PE anti-FOLR1 (Folate Binding Protein)
产品规格：25 tests

产品说明：
Clone   LK26 (See other available formats)
Regulatory Status   RUO
Other Names
Folate receptor alpha, FR-alpha, KB cells FBP, folate binding protein, folate receptor, adult, adult folate-binding protein, ovarian tumor-associated antigen MOv18
Isotype   Mouse IgG2a, κ

描述
叶酸受体（FOLR1），也称为叶酸受体α，是一种在成人中表达的叶酸结合蛋白（FBP）。它对叶酸及其代谢产物具有高亲和力，包括5-甲基四氢叶酸（5-MTF），这是用于DNA合成和半胱氨酸循环的叶酸的生物活性形式。FOLR1介导5-MTF的细胞内递送。FOLR1在多种肿瘤中过表达，包括乳腺、结肠直肠和大脑。
Folate receptor (FOLR1), also known as folate receptor alpha, is a folate-binding protein (FBP) expressed in adults. It has high affinity for folic acid and its metabolites, including 5-methyltetrahydrofolate (5-MTF), the biologically active form of folic acid used for DNA synthesis and the cysteine cycle. FOLR1 mediates intracellular delivery of 5-MTF. FOLR1 is overexpressed in a variety of tumors, including breast, colorectal, and brain.

Product Details
Isotype Control    PE Mouse IgG2a, κ Isotype Ctrl (FC)
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species     Mouse
Immunogen
This antibody was generated against gestational choriocarcinoma cell line, Lu-75 and detects folate-binding protein (FBP).

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

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