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- 详细信息
- 文献和实验
- 技术资料
- 库存：
99
- 英文名：
APC anti-human Folate Receptor β (FR-β)
- 供应商：
北京云肽生物科技有限公司
BioLegend 391706 APC anti-human Folate Receptor β (FR-β)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 391706 APC anti-human Folate Receptor β (FR-β)
产品简介：
产品品牌：BioLegend
产品货号：391706
产品名称：BioLegend 391706 APC anti-human Folate Receptor β (FR-β)
产品规格：100 tests
产品说明：
Clone 94b/FOLR2 (See other available formats)
Regulatory Status RUO
Other Names FR-BETA
Isotype Mouse IgG1, κ
描述
叶酸受体β（FR-β）是叶酸结合受体家族的成员，具有不同的结构身份，但介导叶酸向细胞的转运。FR-β是一种GPI锚定蛋白，对叶酸具有高亲和力。据推测，当叶酸供应量低或细胞快速生长需要提高叶酸摄取以进行甲基化反应（包括DNA生物合成）时，该受体充当叶酸清除剂。虽然这种蛋白质最初被认为是胎盘特异性的，但它也可以存在于其他组织中，并且它可能在类风湿性关节炎患者滑膜巨噬细胞中甲氨蝶呤的转运中发挥作用。
Folate receptors beta (FR-β) is a member of a family of folate binding receptors that have diverse structural identities but mediate transport of folates into cells. FR-β is a GPI-anchored protein with high affinity for folic acid. It is postulated that this receptor function as folate scavengers when folate supply is low or rapid cell growth requires elevated uptake of folate for methylation reactions including DNA biosynthesis. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.
Product Details
Isotype Control APC Mouse IgG1, κ Isotype Ctrl
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Human Folate beta transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Antigen Details
Structure 30 kD, seven disulfide bonds
Distribution
Placenta, monocytes, tissue resident macrophages
Function Transport of folate into cells
Ligand/Receptor Folic Acid
Cell Type Macrophages, Monocytes
Biology Area Immunology
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BioLegend 391706 APC anti-human Folate Receptor β (FR-β)
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