- 询价
- BioLegend
- 846108
- BioLegend
- 2025年11月14日
4 年金牌会员
企业认证
相关产品推荐更多 >
STEMCELL Technologies 04330 MethoCult™H4330/含EPO的基础甲基纤维素培养基
询价
STEMCELL Technologies04534MethoCult H4534 Classic w/out EPO/人甲基纤维素半固体培养基H4534不含EPO
询价
STEMCELL Technologies17962EasySep™ Human Resting CD4+ T Cell Isolation Kit/EasySep™人静息性CD4+T细胞分选试剂盒
询价
赛默飞InvitrogenA6257APTS（8-氨基芘-1,3,6-三磺酸三钠盐）
询价
美天旎Miltenyi130-111-163Vectofusin-1/病毒感染增强剂
询价
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 库存：
99
- 英文名：
BioLegend 846108 FITC anti-complement C3b/iC3b
- 供应商：
北京云肽生物科技有限公司
BioLegend 846108 FITC anti-complement C3b/iC3b
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 846108 FITC anti-complement C3b/iC3b
产品简介：
产品品牌：BioLegend
产品货号：846108
产品名称：BioLegend 846108 FITC anti-complement C3b/iC3b
产品规格：100 tests
产品说明：
Clone 3E7/C3b (See other available formats)
Regulatory Status RUO
Other Names
Complement Component 3, C3b, iC3b, C3bi
Isotype Mouse IgG1, κ
描述
补体C3是一种185kD的糖蛋白，由两条由二硫键连接的链组成。它是经典途径中反应的第四种补体成分。它也是替代和凝集素补体激活途径中的关键蛋白。C3b通过C3转化酶切割蛋白质中的C3a-C3b肽键而从C3蛋白水解产生。C3b可以通过其反应性硫酯与细胞表面碳水化合物或免疫聚集体共价结合。巨噬细胞和中性粒细胞通过补体受体1（CR1，CD35）识别C3b。用C3b对靶表面进行阿pian处理是补体激活的所有三种途径的核心。C3b的蛋白水解无活性形式iC3b是在共因子如因子H存在下，因子I在一个或两个位置切割α链而产生的。当C3b在两个位置被因子I切割时，产生分子量约为2kD的C3b、C3f片段。尽管iC3b的活性低于C3b，iC3b通过CR2（CD21）和CR3（CD11b/CD18）与淋巴和吞噬细胞的相互作用可以扩增靶特异性B和T细胞。iC3b可以被裂解以形成C3c和C3dg。
Complement C3 is a 185 kD glycoprotein composed of two chains linked by a disulfide bond. It is the fourth complement component to react in the classical pathway. It is also a key protein in both the alternative and the lectin complement activation pathways. C3b is proteolytically generated from C3 by cleavage of the C3a-C3b peptide bond in the protein by C3 convertase. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Macrophages and neutrophils recognize C3b by the complement receptor 1 (CR1, CD35). Opsonization of target surfaces with C3b is central to all three pathways of complement activation. The proteolytically inactive forms of C3b, iC3b, are generated by cleavage of the alpha chain at one or two positions by factor I in the presence of co-factors, such as factor H. A fragment of C3b, C3f, with a molecular weight of approximately 2 kD is generated when C3b is cleaved at two positions by factor I. Although iC3b is less active than C3b, iC3b’s interactions with lymphoid and phagocytic cells via CR2 (CD21) and CR3 (CD11b/CD18) can expand target-specific B and T cells. iC3b can be cleaved to form C3c and C3dg.
Product Details
Isotype Control FITC Mouse IgG1, κ Isotype Ctrl (FC)
Verified Reactivity Human
Reported Reactivity Non-Human Primate
Antibody Type Monoclonal
Host Species Mouse
Immunogen Purified native human C3b protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Antigen Details
Structure
C3b is a glycosylated, 176 kD protein that is formed by the cleavage of C3. iC3b is proteolytically derived from C3b and exists as a mixture of 176 and 174 kD proteins.
Distribution
Extracellular fluid, plasma membrane, and serum.
Function
C3b is involved in all three complement pathways and is essential for effective complement activation and presentation of antigens to cells of the adaptive immune system. iC3b is less active than C3b, but the target-bound protein can expand target-specific B-cell and T-cell populations by interacting with lymphoid and phagocytic cells.InteractionC3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Macrophages and neutrophils have receptors, CR1 (CD35), for C3b. iC3b can also function as opsonin, but it binds through CR2 and CR3.
Ligand/Receptor
C3b can bind to Factor B, Factor P, Factor H, Factor I, C5, DAF (CD55), MCP (CD46), and CR1 (CD35). iC3b can interact with CR2 (CD21), and CR3 (CD11b/CD18).
Biology Area
Cell Biology, Complement, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 103035 PerCP anti-mouse/human CD44 IM7 25 ug
BioLegend 103037 Brilliant Violet 570™ anti-mouse/human CD44 IM7 125 uL
BioLegend 103039 Brilliant Violet 421™ anti-mouse/human CD44 IM7 125 uL
BioLegend 103040 Brilliant Violet 421™ anti-mouse/human CD44 IM7 50 ug
BioLegend 103041 Brilliant Violet 785™ anti-mouse/human CD44 IM7 125 uL
BioLegend 103043 Brilliant Violet 510™ anti-mouse/human CD44 IM7 125 uL
BioLegend 103047 Brilliant Violet 605™ anti-mouse/human CD44 IM7 50 ug
BioLegend 103049 Brilliant Violet 650™ anti-mouse/human CD44 IM7 50 ug
BioLegend 103055 PE/Dazzle™ 594 anti-mouse/human CD44 IM7 25 ug
BioLegend 103056 PE/Dazzle™ 594 anti-mouse/human CD44 IM7 100 ug
BioLegend 103059 Brilliant Violet 785™ anti-mouse/human CD44 IM7 50 ug
BioLegend 103061 APC/Fire™ 750 anti-mouse/human CD44 IM7 25 ug
BioLegend 103062 APC/Fire™ 750 anti-mouse/human CD44 IM7 100 ug
BioLegend 103073 Spark YG™ 570 anti-mouse/human CD44 IM7 25 ug
BioLegend 103101 Purified anti-mouse CD45 30-F11 50 ug
BioLegend 103102 Purified anti-mouse CD45 30-F11 500 ug
BioLegend 103103 Biotin anti-mouse CD45 30-F11 50 ug
BioLegend 103105 PE anti-mouse CD45 30-F11 50 ug
BioLegend 103106 PE anti-mouse CD45 30-F11 200 ug
BioLegend 103107 FITC anti-mouse CD45 30-F11 50 ug
BioLegend 103108 FITC anti-mouse CD45 30-F11 500 ug
BioLegend 103109 PE/Cyanine5 anti-mouse CD45 30-F11 25 ug
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验相关实验
Cell Surface Immunofluorescence Staining Protocol
实验试剂 Cell Staining Buffer [ Details:BioLegend Cat. #420201] Red Cell Lysis Buffer [ Details: BioLegend Cat. #420301] 7-AAD Viability Staining Solution[ Details: BioLegend Cat. #420403] TruStain FcX™[ Details: anti
Live‐Cell Immunofluorescence Staining of Human Pluripotent Stem Cells
Stains live MEFs; PE bleaches rapidly hCD13 Biolegend
技术资料暂无技术资料 索取技术资料
BioLegend 846108 FITC anti-complement C3b/iC3b
询价
