BioLegend 645804 FITC anti-p53

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BioLegend 645804 FITC anti-p53
产品简介：
产品品牌：BioLegend
产品货号：645804
产品名称：BioLegend 645804 FITC anti-p53
产品规格：100 tests

产品说明：
Clone   DO-7 (See other available formats)
Regulatory Status  RUO
Other Names   Tumor protein p53 (TP53)
Isotype   Mouse IgG2b, κ

描述
p53是一种53kD的蛋白质，形成四聚体，并作为肿瘤抑制因子和抑制生长和/或侵袭、辐射后细胞周期检查点、DNA修复、凋亡诱导、信号转导和细胞粘附的基因的转录激活因子发挥作用。这种蛋白质在激活时定位于细胞核，并可被基因毒性或其他细胞应激上调。p53通过磷酸化、乙酰化、核糖基化、泛素化和sumoyalization进行修饰；ubiquination通过mdm2靶向p53进行降解。该蛋白与多种蛋白质相互作用，包括mdm2、mdmx、拓扑异构酶I、PML3、Bcl-XL、Bcl-2、Chk1、JNK、p38、HIPK2、CK2、DNA-PK、p300/CBP、PCAF、PARP1和HDAC1-3。突变型p53与p63和p73相关。
p53 is a 53 kD protein that forms tetramers and functions as a tumor suppressor and transcriptional activator of genes that inhibit growth and/or invasion, cell cycle checkpoint after irradiation, DNA repair, apoptotic induction, signal transduction, and cell adhesion. This protein is localized to the nucleus when activated and can be upregulated by genotoxic or other cellular stresses. p53 is modified by phosphorylation, acetylation, ribosylation, ubiquitination, and sumoylation; ubiquination targets p53 for degradation via mdm2. This protein interacts with a variety of proteins including mdm2, mdmx, topoisomerase I, PML3, Bcl-XL, Bcl-2, Chk1, JNK, p38, HIPK2, CK2, DNA-PK, p300/CBP, PCAF, PARP1, and HDAC1-3. Mutant p53 associates with p63 and p73.

Product Details
Isotype Control   FITC Mouse IgG2b, κ Isotype Ctrl
Verified Reactivity  Human
Antibody Type   Monoclonal
Host Species  Mouse
Immunogen   p53 N-terminal linear epitope aa 20-25
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   ICFC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Antigen Details
Structure   Tetramer; 53 kD
Distribution   Nuclear when activated
Function
Tumor suppressor, transcription factor regulates cell cycle checkpoint, apoptosis, DNA integrity

Interaction
mdm2, mdmx, TopoI, PML3, Bcl-XL, Bcl-2, Chk1, JNK, p38, HIPK2, CK2, DNA-PK, p300/CBP, PCAF, PARP1, HDAC1-3; mutant p53 associates with p63, p73
Cell Type   Mesenchymal Stem Cells
Biology Area
Cell Biology, DNA Repair/Replication, Stem Cells

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