BioLegend 806501 Purified (azi

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BioLegend 806501 Purified (azide-free) anti-Tau, 6-18
产品简介：
产品品牌：BioLegend
产品货号：806501
产品名称：BioLegend 806501 Purified (azide-free) anti-Tau, 6-18
产品规格：100 µL

产品说明：
Clone   Tau 12 (See other available formats)
Regulatory Status   RUO
Other Names
PHF-tau, paired helical filament-tau, neurofibrillary tangle protein, microtubule-associated protein tau, isoform 4, G protein beta1/gamma2 subunit-interacting factor 1, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND

Previously   Signet Catalog# 9416-02
Signet Catalog# 9416-05
Signet Catalog# 9416-10
Covance Catalog# SIG-39416
Isotype   Mouse IgG1

描述
Tau蛋白促进微管组装和稳定性。Tau在中枢神经系统的神经元中含量丰富，在星形胶质细胞和少突胶质细胞中低水平表达。tau异常的过度磷酸化、聚集和毒性功能获得与几种神经系统疾病有关，包括阿尔茨海默病（AD）。AD大脑中神经原纤维病变的主要组成部分由异常过度磷酸化的tau的成对螺旋丝（PHF）组成。tau的六种异构体是通过MAPT基因的选择性剪接产生的。这些异构体的区别在于蛋白质C末端的微管蛋白结合结构域3（3R）或4（4R）的数量，以及N末端结构域中的一个（1N）、两个（2N）或没有（0N）插入物。Tau亚型在发育过程中差异表达。
Tau protein promotes microtubule assembly and stability. Tau is abundant in neurons of the central nervous system, and is expressed at low levels in astrocytes and oligodendrocytes. Abnormal hyper-phosphorylation, aggregation, and toxic gain of function of tau is associated with several neurological disorders, including Alzheimer’s disease (AD). The major building block of neurofibrillary lesions in AD brains consists of paired helical filaments (PHFs) of abnormally hyperphosphorylated tau. Six isoforms of tau are generated by alternative splicing of the MAPT gene. These isoforms are distinguished by the number of tubulin binding domains, 3 (3R) or 4 (4R), in the C-terminal of the protein and by one (1N), two (2N), or no (0N) inserts in the N-terminal domain.  Tau isoforms are differentially expressed during development.

Product Details
Verified Reactivity   Human
Antibody Type    Monoclonal
Host Species   Mouse
Formulation
Phosphate-buffered solution (no preservatives or carrier proteins).

Preparation
The antibody was purified by affinity chromatography.
Concentration   1 mg/ml

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application   WB - Quality tested
IHC-P, ELISA - Verified

Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.01 - 0.05 µg per ml. For immunohistochemistry, a concentration range of 0.01 - 0.05 µg/ml is suggested. For ELISA applications, a concentration range of 10 - 100 ng/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.

Distribution
Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol.

Function
Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Interaction
Tau interacts with: Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, and alpha-synuclein.

Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family    Tau

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