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- 技术资料
- 库存：
99
- 英文名：
Recombinant Mouse Prolactin (carrier-free)
- 供应商：
北京云肽生物科技有限公司
BioLegend 757908 Recombinant Mouse Prolactin (carrier-free)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 757908 Recombinant Mouse Prolactin (carrier-free)
产品简介：
产品品牌：BioLegend
产品货号：757908
产品名称：BioLegend 757908 Recombinant Mouse Prolactin (carrier-free)
产品规格：500 µg
产品说明：
Regulatory Status RUO
Other Names Luteotropin, PRL
描述
催乳素是一种由垂体分泌的激素。除了垂体来源外，催乳素还存在于其他组织和细胞中，如脂肪细胞、免疫细胞、皮肤、前列腺、大脑和蜕膜。它最为人所知的作用是使雌性哺乳动物能够产奶。然而，催乳素在免疫功能、胰腺发育、血管生成、生殖、渗透调节和代谢的调节中也发挥着重要作用。这种激素在怀孕和哺乳期间产生的数量越来越多，在产后通过启动和维持泌乳作用于乳腺。小鼠催乳素与人类催乳素具有61%的氨基酸序列同源性。在一项敲除动物研究中，研究表明缺乏催乳素表达的雌性小鼠是不育的。然而，她们表现出自发的母性行为。此外，这些动物在骨髓生成和淋巴细胞生成方面没有表现出改变的迹象，这表明催乳素可能在淋巴细胞和骨髓发育以及骨髓分化中不起不可或缺的作用。流行病学研究表明，循环中高水平的催乳素会增加患癌症的风险。催乳素可能通过JAK2/STAT5信号通路促进乳腺肿瘤的发生。
Prolactin is a hormone that is secreted by the pituitary gland. Besides the pituitary origin, prolactin is found in other tissues and cells such as adipocytes, immune cells, skin, prostate, brain, and the decidua. It is best known for its role in enabling female mammals to produce milk. However, prolactin also plays essential roles in the regulation of immune functions, pancreatic development, angiogenesis, reproduction, osmoregulation, and metabolism. This hormone is produced in increasing amounts during pregnancy and suckling, and it acts on the mammary gland by initiating and maintaining lactation in the postpartum period. Mouse prolactin has a 61% amino acid sequence homology with its human counterpart. In a knockout animal study, it was shown that female mice lacking the expression of prolactin are infertile. Nevertheless, they manifest spontaneous maternal behaviors. In addition, these animals show no sign of alterations in myelopoiesis and lymphopoiesis, suggesting that prolactin may not play an indispensable role in lymphocyte and myeloid development and myeloid differentiation. Epidemiological studies have demonstrated that circulating high levels of prolactin increase the risk of breast cancer. Prolactin may promote mammary tumor initiation via the JAK2/STAT5 signaling pathway.
Product Details
Source
Mouse Prolactin, amino acids Met-(Leu32-Cys228) (Accession# NM_011164), was expressed in E.coli.
Molecular Mass
The 198 amino acid recombinant protein has a predicted molecular mass of approximately 22.5 kD. The protein migrates at approximately 22 kD under DTT-reducing conditions and at approximately 20 kD under non-reducing conditions respectively by SDS-PAGE. The predicted N-terminal amino acid is Met.
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Formulation
0.22 µm filtered protein solution is in PBS, pH 7.2.
Endotoxin Level
Less than 0.1 EU per µg of protein as determined by the LAL method.
Concentration
10 and 25 µg sizes are bottled at 200 µg/mL. 100 µg size and larger sizes are lot-specific and bottled at the concentration indicated on the vial. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.
Storage & Handling
Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to six months, or at -70°C or colder until the expiration date. For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored at -20°C or colder. Stock solutions can also be prepared at 50 - 100 µg/mL in appropriate sterile buffer, carrier protein such as 0.2 - 1% BSA or HSA can be added when preparing the stock solution. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Activity
Mouse Prolactin induces the proliferation of Nb2-11 rat lymphoma cells in a dose dependent manner. The ED50 = 0.2 - 1.0 ng/ml.
Application Bioassay
Antigen Details
Structure Monomer.
Distribution
Anterior pituitary (lactotrophs), immune cells, brain, decidua, adipocytes, and cholangeocytes.
Function
Lactogenic activity and breast and prostate cancer development. Prolactin secretion is negatively controlled by hypothalamic dopamine. Prolactin releasing factors include the thyrotropin-releasing hormone, vasoactive intestinal polypeptide, vasopressin, serotonin, angiotensin II, and oxytocin.
Interaction Mammary epithelial cells.
Ligand/Receptor PRLR (prolactin receptor).
Bioactivity
Mouse prolactin induces the proliferation of Nb2-11 rat lymphoma cells.
Cell Type Hematopoietic stem and progenitors
Biology Area Stem Cells
Molecular Family Cytokines/Chemokines, Growth Factors
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BioLegend 757908 Recombinant Mouse Prolactin (carrier-free)
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