BioLegend 680202 Purified anti

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BioLegend 680202 Purified anti-AKT2
产品简介：
产品品牌：BioLegend
产品货号：680202
产品名称：BioLegend 680202 Purified anti-AKT2
产品规格：100 µg 

产品说明：
Clone   P81B6 (See other available formats)
Regulatory Status   RUO
Other Names
V-Akt Murine Thymoma Viral Oncogene Homolog 2, Protein Kinase B Beta, Rac Protein Kinase Beta, RAC-PK-Beta, PKB Beta, PRKBB, PKBB, HIHGHH, PKBBETA, RAC-BETA
Isotype   Mouse IgG2b, κ

描述
AKT（蛋白激酶B，PKB）是一种丝氨酸/苏氨酸激酶，在调节细胞存活、胰岛素信号传导、血管生成和肿瘤形成中发挥关键作用。AKT有三种亚型——AKT1、2和3，也称为PKBα、β和γ）。越来越多的证据表明，AKT1、2和3在癌症的发生和发展中发挥着独特的作用。AKT2在癌症中被扩增或过表达，其频率高于AKT1。AKT2也与II型糖尿病密切相关，是磷脂酰肌醇3激酶/Akt/雷帕霉素哺乳动物靶点（PI3K/mTOR）信号轴的关键参与者。AKT2的失调与干细胞样特性的获得有关，这些特性负责侵袭性和肿瘤进展、转移性扩散和化疗耐药性。
AKT (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis, and tumor formation. There are three isoforms of AKT- AKT1, 2, and 3, which are also known as PKBα, β, and γ). Increasing evidence suggests that AKT1, 2, and 3 plays an unique role in breast cancer initiation and progression. AKT2 is amplified or overexpressed in cancer with a higher frequency than those found with AKT1. AKT2 is also closely linked to Type II diabetes and is a pivotal player in the Phosphatidylinositol 3 kinase/Akt/Mammalian target of rapamycin (PI3K/mTOR) signaling axis. The deregulation of AKT2 has been associated with acquisition of stem cell-like properties, responsible for invasiveness and tumor progression, metastatic spread, and chemoresistance.

Product Details
Verified Reactivity   Human, Mouse
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen
Purified recombinant fragment (a.a. 2-149) of human AKT2 expressed in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation
The antibody was purified by affinity chromatography.
Concentration   0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application   WB - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
481 amino acids with a predicted molecular weight of approximately 56 kD.
Distribution
Cytoplasm, nucleus, cell membrane, and peripheral membrane protein.

Function
AKT2 plays a ket role in regulating cell survival, insulin, signaling, angiogenesis, and tumor formation.
Interaction
BTBD10, KCTD20, MTCP1, TCL1A, TCL1B, CLK2, PBH2, TRAF6, and CLIP3.

Biology Area
Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Immunology, Innate Immunity, Neuroscience, Signal Transduction, Ubiquitin/Protein Degradation
Molecular Family    Protein Kinases/Phosphatase

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