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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
CD332; KGFR
- 抗体英文名：
CD332; KGFR
- 靶点：
-
- 浓度：
2mg/ml
- 应用范围：
ELISA
- 宿主：
Human
- 供应商：
爱必信(上海)生物科技有限公司
- 库存：
现货
- 级别：
-
- 目录编号：
-
- 抗原来源：
-
- 保质期：
Store at 4°C for one month, aliquot and store at -20°C or -80°C for long time. Avoid repeated freeze/thaw cycles.
- 适应物种：
Human
- 标记物：
-
- 克隆性：
-
- 保存条件：
Store at 4°C for one month, aliquot and store at -20°C or -80°C for long time. Avoid repeated freeze/thaw cycles.
- 形态：
液态
- 亚型：
-
- 免疫原：
-
- 规格：
10uL/25uL/100uL/1mL
| 规格： | 10uL | 产品价格： | ￥200.0 |
|---|---|---|---|
| 规格： | 25uL | 产品价格： | ￥600.0 |
| 规格： | 100uL | 产品价格： | ￥2100.0 |
| 规格： | 1mL | 产品价格： | ￥13200.0 |
| 概述 | |
| 别名 | Fibroblast growth factor receptor 2; CD332; KGFR; Keratinocyte growth factor receptor; K-sam |
| 宿主 | Human |
| 反应种属 | Human |
| 应用 | ELISA |
| 性能 | |
| 浓度 | 2mg/ml |
| 纯化方法 | Protein A affinity column |
| 类型 | Monoclonal antibody |
| 同种型 | Human IgG1, lambda |
| 储存/保存方法 | Store at 4°C for one month, aliquot and store at -20°C or -80°C for long time. Avoid repeated freeze/thaw cycles. |
| 存储溶液 | PBS, 0.03% Proclin 300 |
| 靶标 | |
| 背景说明 | Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor. FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. On a molecular level these signals mediate cell division, growth and differentiation. Recombinant Human monoclonal antibody expressed in HEK293 binding to Human FGFR2. This is a novel fibroblast growth factor receptor 2 (FGFR2) directed antibody used for cancer therapy. FGFR2 is expressed in a range of tumor types such as gastric, breast, HNSCC, pancreatic and ovarian cancers. FGFR2 has been described to promote tumor growth and survival and play a role in chemotherapy resistance. |
| 细胞定位 | Membrane |
| UniProt | P21802 |
实验结果图：
FGFR2 Human recombinant mAb (BAY 1179470, dilutions start from 2ug/ml) can bind to Immobilized recombinant Human FGFR2IIIc his tag at 0.5μg/ml (50μL/well) as coating antigen. EC50=13.53 ng/ml
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