BioLegend 440807 LEGEND MAX™ H

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BioLegend 440807 LEGEND MAX™ Human CCL5 (RANTES) ELISA Kit
产品简介：
产品品牌：BioLegend
产品货号：440807
产品名称：BioLegend 440807 LEGEND MAX™ Human CCL5 (RANTES) ELISA Kit
产品规格：1 Pre-coated Plate

产品说明：
Regulatory Status  RUO
Other Names
Human CCL5 (RANTES) Precoated ELISA Kit, D17S136E, SCYA5, SISd, TCP228

描述
CCL5，也称为RANTES，是CC趋化因子家族的成员。CCL5的前体含有91个氨基酸，其中N端信号肽由23个氨基酸组成，被切割生成68个氨基酸的成熟蛋白（7.8 kD）。人类成熟的CCL5与马，猪，牛，小鼠，大鼠和犬CCL5具有82%-90%的氨基酸序列同一性。

CCL5由T细胞和单核细胞/巨噬细胞表达。它在通过受体CCR1，CCR3，CCR4和CCR5将白细胞募集到炎症部位中起积极作用。CCL5诱导某些自然杀伤（NK）细胞的增殖和活化。它还抑制HIV-1的进入和感染。此外，CCL5在癌细胞的迁移和转移中起着至关重要的作用。CCL5 水平升高见于黑色素瘤、乳腺癌、宫颈癌、前列腺癌、胃癌和胰腺癌。
BioLegend的LEGEND MAX™人CCL5（RANTES）ELISA试剂盒是一种夹心酶联免疫吸附测定（ELISA），具有96孔试纸板，预包被人CCL5特异性抗体。该试剂盒专为准确定量来自细胞培养上清液、血清、血浆和其他生物体液中的人CCL5而设计。该试剂盒使用即用型试剂进行了分析验证。
CCL5, also known as RANTES, is a member of the CC family of chemokines. The precursor of CCL5 contains 91 amino acids, with an N-terminal signal peptide of 23 amino acids which is cleaved to generate the 68 amino acids mature protein (7.8 kD). Human mature CCL5 shares 82% - 90% amino acid seqeuence identity with equine, porcine, bovine, mouse, rat and canine CCL5.

CCL5 is expressed by T cells and monocytes/macrophages. It plays an active role in recruiting leukocytes into inflammatory sites through receptors CCR1, CCR3, CCR4, and CCR5. CCL5 induces the proliferation and activation of certain natural killer (NK) cells. It also inhibits HIV-1 entry and infection. In addition, CCL5 plays a crucial role in the migration and metastasis of cancer cells. Increased CCL5 levels are found in melanoma, breast, cervical, prostate, gastric, and pancreatic cancers.

BioLegend's LEGEND MAX™ Human CCL5 (RANTES) ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with an antibody specific for human CCL5. This kit is specifically designed for the accurate quantitation of human CCL5 from cell culture supernatant, serum, plasma, and other biological fluids. This kit is analytically validated with ready-to-use reagents.

Product Details
Verified Reactivity   Human
Application   ELISA

Antigen Details
Cell Sources
T cells, monocytes/macrophages, mesangial cells, platelets
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family    Cytokines/Chemokines

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