产品说明: Regulatory Status RUO Other Names CTLA-4 Pre-coated ELISA Kit
描述 CTLA4(细胞毒性T淋巴细胞抗原4),也称为CD152,是一种在免疫系统中起重要调节作用的蛋白质。CTLA4在辅助性T细胞表面表达,并向T细胞传递抑制信号。CTLA4基因突变与各种自身免疫性疾病有关,如系统性红斑狼疮、胰岛素依赖性糖尿病和其他自身免疫性疾病。 最近发现的CTLA-4基因的新转录本可能代表CTLA-4的天然可溶性形式(sCTLA-4)显示,20名自身免疫性甲状腺疾病(ATD)患者中有11名具有高浓度的sCTLA-4,而30名看似健康的志愿者中只有1名含有可测量的水平。sCTLA-4免疫反应性通过与B7.1结合而受到抑制,表明sCTLA-4是一种功能受体。sCTLA4 在对 HIV 感染免疫细胞的初始免疫反应中也发挥作用,以及 CD-1 途径和其他途径。 BioLegend 人溶性 CTLA-4 LEGEND MAX™ ELISA 试剂盒是一种夹心酶联免疫吸附测定 (ELISA),具有 96 孔微量滴定试纸板,预包被捕获抗体。 该 ELISA 试剂盒专为准确定量细胞培养上清液、血清、血浆或其他生物体液中的 sCTLA-4 而设计。它们经过分析验证,可提供即用型试剂。 CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein that plays an important regulatory role in the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. Mutations in the CTLA4 gene have been associated with various autoimmune diseases, such as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune diseases.
A recently identified novel transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4 (sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD ) had a high concentration of sCTLA-4, whereas only 1 of 30 apparently healthy volunteers contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. sCTLA4 also plays a role in the initial immune response to infection of immune cells by HIV, along with the CD-1 pathway and others.
The BioLegend Human Soluble CTLA-4 LEGEND MAX™ ELISA kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with 96 well microtiter strip plates that are pre-coated with a capture antibody.
This ELISA kit is specifically designed for the accurate quantitation of sCTLA-4 from cell culture supernatant, serum, plasma or other biological fluids. They are analytically validated and provide ready to use reagents.
Product Details Verified Reactivity Human Application ELISA
Antigen Details Cell Sources Activated T cells and B cells Biology Area Immunology, Inhibitory Molecules Molecular Family CD Molecules, Immune Checkpoint Receptors, Soluble Receptors