BioLegend 396102 Purified anti

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BioLegend 396102 Purified anti-human/mouse/rat MR1
产品简介：
产品品牌：BioLegend
产品货号：396102
产品名称：BioLegend 396102 Purified anti-human/mouse/rat MR1
产品规格：100 µg

产品说明：
Clone  8F2.F9 (See other available formats)
Regulatory Status  RUO
Other Names
Major Histocompatibility Complex Class I-related, HLALS
Isotype   Mouse IgG1, κ

描述
MHC相关蛋白1，也称为MR1，是一种非经典的MHC I类分子，在哺乳动物中高度保守，特别是在其α1 / α2结构域中。MR1是粘膜相关不变T（MAIT）细胞发育和扩增所必需的。MR1的转录本普遍表达，但其在细胞表面的表达似乎是配体依赖性的。MR1参与细菌生物合成途径中维生素衍生化合物的呈现。
MHC-related protein 1, also known as MR1, is a nonclassical MHC class I molecule highly conserved in mammals, particularly in its α1/α2 domains. MR1 is required for the development and expansion of the mucosal-associated invariant T (MAIT) cells. The transcripts for MR1 are ubiquitously expressed, but its expression on the cell surface seems to be ligand-dependent. MR1 is involved in the presentation of vitamin-derived compounds from bacterial biosynthetic pathways.

Product Details
Isotype Control   Purified Mouse IgG1, κ Isotype Ctrl
Verified Reactivity   Human, Mouse, Rat
Reported Reactivity   Cow
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen
Chimeric mMR1/L molecule (mMR1 [alpha1-alpha2 domain]/Ld [alpha3 cytoplasmic tail]) soluble, recombinant protein secreted by insect cells was used to immunize MR1 KO mice

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation
The antibody was purified by affinity chromatography.
Concentration   0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application   FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes
This antibody is noted to cross-react to over-expressed mouse, rat, bovine (cow) and human MR11. This clone does not cross-block clone 26.5 based on in-house testing.

Antigen Details
Structure
Member of the MHC class I family, 1 Ig-like C1-type domain, forms heterodimer with B-2 Microglobulin.

Distribution
MR1 transcripts are ubiquitously expressed, but its expression in the cell surface seems to be ligand-dependent.

Function
Antigen presentation, required for development and expansion of the mucosal-associated invariant T (MAIT) cells.

Ligand/Receptor
α-mannosyl ceramide derivatives, 6-formyl pterin, derivatives from bacterial riboflavin biosynthetic pathway).
Biology Area   Immunology, Innate Immunity
Molecular Family   MHC Antigens

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