BioLegend 374509 FITC anti-hum

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BioLegend 374509 FITC anti-human CD274 (B7-H1, PD-L1)
产品简介：
产品品牌：BioLegend
产品货号：374509
产品名称：BioLegend 374509 FITC anti-human CD274 (B7-H1, PD-L1)
产品规格：25 tests

产品说明：
Clone   MIH3 (See other available formats)
Regulatory Status   RUO
Other Names
Programmed cell death ligand 1 (PD-L1), B7 homolog 1 (B7-H1), B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Isotype   Mouse IgG1, κ

描述
CD274，也称为PD-L1和B7-H1，是I型跨膜糖蛋白，可作为CD279（PD-1）的配体。这种相互作用被认为可以调节对微生物的反应和维持自我耐受所需的刺激和抑制信号之间的平衡。CD274以IL-2依赖性和CD279非依赖性方式参与T细胞增殖和IL-10和IFN-γ的产生。相互矛盾的数据表明，CD274可以抑制T细胞增殖和细胞因子的产生，或者增强T细胞活化。其他研究表明，CD274可能是双向信号，对其在多种细胞类型中的表达提出了有趣的意义，包括T细胞和B细胞，抗原呈递细胞和非造血细胞。
Description
CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and non-hematopoietic cells.

Product Details
Isotype Control    FITC Mouse IgG1, κ Isotype Ctrl (FC)
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen     Human PD-L1-transfected cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Antigen Details
Structure
Type 1 transmembrane protein, member of the B7 family, 40kD.
Distribution
T cells, B cells, NK cells, monocytes/macrophages, granulocytes and dendritic cells.

Function
CD274 is involved in the costimulatory signal, essential for T lymphocyte proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-CD1-independent manner. Its interaction with PD-1-CD1 inhibits T-cell proliferation and cytokine production.
Ligand/Receptor   PD-1 (CD279), B7-1 (CD80).

Cell Type
T cells, B cells, NK cells, Monocytes, Macrophages, Granulocytes, Dendritic cells

Biology Area
Immunology, Cancer Biomarkers, Costimulatory Molecules

Molecular Family
Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors

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