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99
- 英文名：
PE/Cyanine7 anti-human CD199 (CCR9)
- 供应商：
北京云肽生物科技有限公司
BioLegend 358910 PE/Cyanine7 anti-human CD199 (CCR9)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 358910 PE/Cyanine7 anti-human CD199 (CCR9)
产品简介：
产品品牌：BioLegend
产品货号：358910
产品名称：BioLegend 358910 PE/Cyanine7 anti-human CD199 (CCR9)
产品规格：100 tests
产品说明：
Clone L053E8 (See other available formats)
Regulatory Status RUO
Other Names
GPR 9-6, GPR28, CDw199, Chemokine Receptor 9
Isotype Mouse IgG2a, κ
描述
人CD199，也称为CCR9，是G蛋白偶联受体家族的成员，参与胸腺中的T细胞发育和肠道相关的免疫反应。它在胸腺细胞的不同阶段高度表达，并在CD4 + CD8 +细胞上上调。CCR9 在上皮内和小肠中 γ/δ T 细胞上的表达已有报道。CCR9与其配体CCL25（TECK，胸腺表达的趋化因子）的相互作用可能指导胸腺中发育中的T细胞的运输和肠道特异性免疫记忆的产生。
Human CD199, also known as CCR9, is a member of the G protein coupled receptor family and is involved in T cell development in the thymus and in the gut-associated immune response. It is highly expressed on different stages of thymocytes and upregulated on CD4+ CD8+ cells. Expression of CCR9 on γ/δ T cells in the intraepithelial and small intestine has been reported. The interaction of CCR9 with its ligand CCL25 (TECK, thymus-expressed chemokine) may direct the trafficking of developing T cells in the thymus and the generation of gut-specific immunological memory
Product Details
Isotype Control PE/Cyanine7 Mouse IgG2a, κ Isotype Ctrl
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Cells transfected with human CCR9
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Antigen Details
Structure
A member of G-protein coupled receptors which contains seven transmembrane domains. Human CCR9 has above 80% amino acid sequence homology with its mouse counterpart.
Distribution
CD4+CD8+ thymocytes, γ/δ T cells, subset of memory T cells
Function
May direct the trafficking of developing T cells in the thymus and generation of gut-specific immunological memory; co-receptor for HIV-1
Ligand/Receptor CCL25
Cell Type T cells, Thymocytes
Biology Area Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
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BioLegend 358910 PE/Cyanine7 anti-human CD199 (CCR9)
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